Kate M. @KateM000000

A four-year investigation reveals that millions of euros’ worth of agricultural products from Israeli settlements enter European markets unlawfully. A complete European Union-wide ban is needed on these war-crime products. trib.al/2KkzULc

1/n 🚨New preprint alert!🚨Excited to share my thesis work live on #bioxriv uncovering a previously overlooked pathway from the external globus pallidus (GPe) to the nucleus reticularis thalami (nRT)! biorxiv.org/content/10.648…

🚨 BREAKING: Palantir has received a contract from the Trump Administration to accumulate and centralize data on Americans.

keyboard_arrow_left Previous keyboard_arrow_right Next

Endometriosis is usually thought of as a gynaecological condition, but a huge study shows it has links with cholesterol levels, inflammation and an altered microbiome newscientist.com/article/252940…

Scientists May Have Found a Biological Signature of Consciousness lifeboat.com/blog/2026/06/s…

Here, a soy protein-yogurt-honey powdered meal replacement did not improve chronic low-grade inflammation and had limited effects on gut microbiota in individuals with excess body weight.

Let’s stop calling it settler violence. It is settler TERROR. These criminals roam the West Bank with impunity, and the world stays silent.

מחוץ לעדר/ kivsa shchora @masafering

4 months ago

The horrifying assault on our friend Abu Ayoub in the village of Fakhit, as captured by security cameras. Abu Ayoub is currently hospitalized with a fractured skull after undergoing emergency surgery during the night.

163 2K 2K 742K 285

Female Clinical Resilience Despite Pathologic Risk in Alzheimer Disease. jamanetwork.com/journals/jama/…

Dietary Polyphenols in Brain Aging: Molecular Mechanisms and Implications for Neurodegeneration mdpi.com/2072-6643/18/9…

keyboard_arrow_left Previous keyboard_arrow_right Next

Here's the NY Times article everyone is talking about. A gift from me to you. 👀 nytimes.com/2026/06/10/mag…

Our latest preprint is out, where we investigated a profound SARS-CoV-2 epidemiological anomaly: BA.3.2.2 is selectively infecting children. Here, we show that the lack of ancestral-strain immune imprinting is promoting BA.3.2.2 pediatric infections. 1/9 biorxiv.org/content/10.648…

The epigenetic control of inflammaging in skeletal muscle and adipose tissue sciencedirect.com/science/articl…

'Epigenetic noise in the aging brain: tuning neuronal vulnerability to neurodegeneration' by Xinyang Yin, Houchun Zhang, Ru Zhang, Jianhuang Xue & Yujun Hou cell.com/trends/neurosc…

A new @SciImmunology study highlights an approach called Effero-seq, which shows that efferocytosis of tumor cells in mouse models of melanoma can induce protumoral functions in macrophages. scim.ag/4oivO2T

In my model, I suggest there are many conditions that downregulate the glucocorticoid receptor ( ie. glucocorticoid resistance via childhood trauma or sleep deprivation). What happens when the glucocorticoid receptor is downregulated? In normal circumstances there is a GR- orexin- stimulating norepinephrine axis? When glucocorticoid receptors (GR) are downregulated, the brain loses its primary off-switch for the body's stress response. This structural deficit leads to a condition known as glucocorticoid resistance, causing the [hypothalamic-pituitary-adrenal (HPA) axis](pmc.ncbi.nlm.nih.gov/articles/PMC62…) to become hyperactive, unchecked, and chronically locked in a survival state. [1, 2] Based on the orexin-norepinephrine-GR circuit discussed previously, GR downregulation triggers several distinct neurobiological consequences: ## 1. Chronic Hyper-Arousal and Sleep Fragmentation * Loss of the Brake: Under normal conditions, cortisol binds to GRs to suppress orexin and norepinephrine production, settling the nervous system down. * Orexin Runaway: With fewer functional GRs, this negative feedback loop fails. Orexin neurons fire continuously without their chemical brake. [2] * Norepinephrine Flooding: Uninhibited orexin keeps the locus coeruleus in a state of constant excitation. This results in an uncontrolled broadcast of norepinephrine across the brain, producing chronic anxiety, hyper-vigilance, and fragmented sleep. [3, 4] ## 2. HPA Axis Hyperactivity (Systemic Cortisol Rises) * Feedback Failure: The hypothalamus and pituitary gland rely on GRs to sense circulating cortisol levels. * Blinded Brain: Because downregulation desensitizes these target cells, the brain mistakenly perceives a cortisol deficiency. * HPA Runaway: The hypothalamus responds by continually pumping out Corticotropin-Releasing Hormone (CRH). This forces the adrenal cortex to produce abnormally massive quantities of cortisol, which can eventually lead to systemic tissue damage, metabolic issues, and immune suppression. [2, 5, 6, 7, 8, 9] ## 3. Neuroinflammation and Brain Atrophy * Pro-Inflammatory Shift: At baseline, GR activation keeps microglia (the brain's immune cells) in a calm, anti-inflammatory state. * Immune Disinhibition: When GRs are sparse or desensitized, microglia shift into an aggressive, pro-inflammatory profile. They release cytokines that damage surrounding neural structures, particularly inside the hippocampus. [10] * Synaptic Loss: This sustained neuroinflammatory environment halts the production of Brain-Derived Neurotrophic Factor (BDNF), leading to the degradation of dendritic spines and a decreased capacity for learning and memory retention. [11] ## 4. Psychological Vulnerability * Depression and Trauma: Data published on [PubMed](pubmed.ncbi.nlm.nih.gov/30576626/) and [PMC](pmc.ncbi.nlm.nih.gov/articles/PMC64…) strongly correlates GR downregulation with major depressive disorder (MDD), burnout syndrome, and PTSD. [12] * Learned Helplessness: The combination of low neuroplasticity, perpetual biochemical panic (high norepinephrine), and metabolic exhaustion physically traps the brain in a state of learned helplessness. [1] [pmc.ncbi.nlm.nih.gov](pmc.ncbi.nlm.nih.gov/articles/PMC62…) [2] [pbi.nlm.nih.gov](pmc.ncbi.nlm.nih.gov/articles/PMC59…) [3] [pmc.ncbi.nlm.nih.gov](pmc.ncbi.nlm.nih.gov/articles/PMC67…)

Adults who feel older than their chronological age report significantly worse sleep outcomes, including elevated insomnia symptoms, lower sleep regularity, and greater sleep-related daytime impairment. ow.ly/Iy3t50Z6S4h

After more than a decade of clinical faith in Vitamin D supplementation, one of the largest and most expensive randomized controlled trials in nutrition delivered a verdict that was largely ignored: A Vitamin D pill does absolutely nothing Not for cancer incidence, not for cardiovascular events, not for all-cause mortality The VITAL trial, funded by the National Institutes of Health at a cost exceeding $40 million, followed 25,871 adults for an average of 5.3 years, administering 2000 IU of vitamin D3 daily against placebo By the trial’s end, there was no statistically significant reduction in invasive cancer, no reduction in heart attack, stroke, or cardiovascular death, and no reduction in mortality from any cause This is the data modern dermatology built its supplementation protocols on, and it failed spectacularly The default response from mainstream practitioners was to question the dose, question the duration, question the baseline levels What they did not question was the premise that a single orally administered molecule is a functional substitute for sunbathing when UV-B is available That assumption is the problem, and the circadian photobiology that dismantles it has been accumulating for years You don’t get any of the goods that the sun provides through a pill. Lumisterol, tachysterol, urocanic acid, all of the metabolites shown in the second picture, UV-A induced nitric oxide, mitochondrial stimulation, the full spectrum, so forth We love to see it Another circadian dub for heliotherapy Full article included below

keyboard_arrow_left Previous keyboard_arrow_right Next

Dr. Hussam Abu Safiya’s message to the court today as relayed by his attorney: “I am a pediatrician. I provide medical care to patients, the injured, and vulnerable people in the Gaza Strip. I have carried out my work in accordance with international law and humanitarian standards. My detention is unjust and arbitrary.”

Good news: Happiness isn’t something you either have or don’t have. It is something you can actively cultivate. Start here, advises @SauerZavala psychologytoday.com/us/blog/self-m…

In a new @NatureNeuro study led by @UCSF neurosurgeon @EWinklerMDPhD, researchers profiled the cells in human aneurysms, identifying the changes that make a rupture more likely and new opportunities for therapeutic intervention: nature.com/articles/s4159… @mtlawton @BarrowNeuro