Matthew Robbins @offcycle

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks. For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery. We were treating the smoke while the fire kept burning. The fire is inflammation. And the evidence is now overwhelming. The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night. AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect. This isn't theoretical. This is measurable. Right now. On a scan you can get this month. Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach. And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving. But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators. And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain. Here's what this means for you right now — today: Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture. If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this. Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed. Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported. And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin. I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances. The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen. You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel. The myth that normal cholesterol means you're safe has cost more lives than I can count. We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting. Prevention is the new cure. And the science to make it real is no longer coming. It's here.

Cincinnati mentioned 🥹

OnlMaps @onlmaps

3 days ago

U.S. Cities Not Requiring State Names utilizing Associated Press Style

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Therye called beans

` @ymmayerr

5 days ago

Can someone just invent a protein pill? I physically CANNOT eat 30g of protein a meal it’s just impossible

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A guy sat at his laptop ready to permanently delete his 15-year-old Gmail account. He was getting 400 spam emails a day. Fake Best Buy receipts. Phishing links from "Netflix." Cryptic extortion threats. He hovered his mouse over "Delete Account" and sighed: "I just want peace." His coworker, a former email deliverability engineer, looked over his shoulder. "Before you nuke 15 years of contacts and data, let me show you something. Your email isn't broken. It's weaponized. There are 22 ways you've been leaving the door wide open. Google won't tell you this because the data collection feeds their entire ad engine. Give me 14 minutes." Here's what she showed him:

The lack of morning weather balloons launched across the western and central U.S. is having a real, tangible impact on degrading forecast quality. We can't look at weather balloon data that doesn't exist. We can't pump nonexistent data into models. We can't rely as heavily on models that don't "know" what's happening above our heads. Today's severe weather forecast is less certain because we don't have weather balloon data to confirm the strength of jet stream winds aloft. This is extremely frustrating, and is the result of logistical, organizational, political and budgetary decisions.

Everyone needs to know the origin of the word “rune.” When ancient Germanics formed their own alphabet, they called the letters *rūnōz or “whispers,” because as your eyes followed them, they spoke to you, silently. Reading is magic to a people at the dawn of literacy, who haven’t yet learned to take the miracle for granted.

These are the brand new disguised Automated License Plate Reader cameras in Arizona The large yellow plastic barrels are camouflaged housings designed to look like construction equipment They are being deployed in remote desert areas along highways These new camouflaged cameras are a partnership between Flock and law enforcement and the plan is to use them extensively to track vehicle movement and broader surveillance We are witnessing the surveillance state being established in America… this only ends in mass surveillance

God forbid we have fun sometimes

Her Apple Watch battery dropped to 78% after just one year. She wore it daily. She charged it overnight. She used it like every other Apple Watch owner she knew. Yet her battery had degraded faster in 12 months than her iPhone had in 3 years. She took it to the Genius Bar, expecting them to confirm it was defective. The technician ran every diagnostic. "Your watch isn't broken. It's just been running 24 hours a day doing things it doesn't need to do. There are 4 default settings on every Apple Watch that hammer the battery overnight. Apple knows. They've known since the first Series 1 launched. They don't change the defaults." She asked why. He gave the same answer Apple Store employees have learned to give silence. Then he opened the Watch app on her iPhone and walked her through everything. Here's what he showed her. 🧵

Finnish scientists trucked in real forest dirt and grass and laid it over the gravel at four daycare yards. They let the kids dig around in it for a month. The blood tests came back with changes the researchers hadn’t expected to see so fast or so clear. The study ran at ten daycares in two Finnish cities with 75 kids aged three to five. Four of the yards got the forest treatment: about a tennis court worth of soil and grass laid over the gravel, plus planters and peat blocks the kids could dig and climb on. Three others stuck with their normal gravel yards. The last three were daycares where the kids were already visiting real forests every day. After one month, the variety of bacteria living on the kids’ skin shot up, and the kind that helps train the skin’s immune defenses jumped the most. Their gut bacteria started to look like the gut bacteria of the forest-visiting kids. Their blood showed more of the immune cells whose job is to keep the body from freaking out at harmless stuff like pollen and peanuts, and overall inflammation dropped. The kids on the plain gravel yards showed none of this. Childhood asthma in the US doubled between 1980 and 1995. Food allergies in kids jumped 50 percent between 1997 and 2011, then jumped another 50 percent between 2007 and 2021. And peanut allergies in one-year-olds tripled between 2001 and 2017. The Finnish researchers think one of the reasons is simple: kids today don’t get dirty enough. 37 percent of American preschoolers now spend an hour or less outside on a normal weekday. Their immune systems are getting trained in environments stripped of the bacteria humans have always lived around. Aki Sinkkonen, who led the study, put it in plain words: “It would be best if children could play in puddles and everyone could dig organic soil.” The Finnish government is now helping pay for daycares across the country to make the same changes.

ChiefHerbalist @HerbalistChief

2 weeks ago

We need to apologize to our ancestors.

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Your official guide for bees this summer

🚨 US House Energy/Commerce Committee today amended the Sunshine Protection Act into the Motor Vehicle Modernization Act. If approved by Congress, it would mandate permanent Daylight Saving Time in all states that don’t self-exempt in advance, with no option for exemption after taking effect. 🧐 Permanent DST is a mandate to start work/school an hour earlier than Standard Time in unnatural darkness all winter. It would put sunrise in most states past 8am for 3+ months, and past 8:45am for 1+ weeks. It chronically deprives sleep, decreases productivity (by 5%), and increases illnesses and accidents (by 20%). It was last implemented in the US in 1974 and repealed the same year following deaths and disruptions to commerce. 👉 Tell your US House reps asap to amend MVMA (H.R.7389) to remove SPA (H.R.139) or to reword for nationwide restoration of permanent Standard Time with a clearer option for the minority of states to choose unhealthy/unsafe permanent DST by advancement of their own time zones if so strongly desired (though why DST proponents don’t simply start their own days an hour early remains boggling).

Levie’s Law of AI Psychosis: The farther away you are from the actual work the more confident you are that humans are no longer needed I like it

Aaron Levie @levie

2 weeks ago

CEOs are uniquely prone to AI psychosis because they’re sufficiently distant from the last mile of work that still has to happen to generate most value with AI. So when they play with AI, they see the happy path results, often not considering the next 10 or 20 things that have

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This is probably the best look at the shockwaves I’ve seen from the latest Starship flight. Captured from a GoPro I clamped onto a proper camera to record simultaneous video. (I’ll show you the photo the better camera took in the reply)

The most batshit crazy video I’ve ever seen. HOLY MOLY CANOLI.

Cameron Schwartz @nyoomtm

3 weeks ago

Liftoff of Starship V3, from the dunes right outside the pad. This is the most insane shockwave action I have ever seen on video. Absolutely mad. 📽️ Me for @WeAreSpaceScout

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Man, Remco nailed it in the 60's when they asked themselves, "What do boys really want?"

Party of fiscal responsibility, my ass

unusual_whales @unusual_whales

3 weeks ago

BREAKING: U.S. national debt officially hits $39 trillion, adding approximately $5 billion a day since October, per FORTUNE

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Here is a huge positive to modern life that gets no press. I have an old 2009 Toyota, and the AUX port crapped out about a year ago. Went to YouTube. Young, enthusiastic guy explains how to fix it. It is not obvious - involves taking the dashboard apart in a counter-intuitive way, but once you see it, it's a 15 minute fix. There are actually dozens of videos showing how to do this, and they collectively have well over 200k views. Had this happened in 1995, I would have just lived with it. But the combo of the replacement AUX jack available from Amazon and the video of the simple (but not obvious) fix, I fixed it. I HAVE DONE THIS DOZENS OF TIMES. Replaced the control panel of my dishwasher. Replaced the ice maker in the fridge. Fixed a wonky sanding head on my drill press. Mastered a bandsaw technique that I use for my sculpture. On and on and on... I think it is likely no exaggeration to say billions of fixes and skill upgrades have been performed worldwide that would not have been performed if it were not for the instruction freely given peer-to-peer on YouTube. Take a moment to be happy about this. The busted item keeps performing, rather than going to the landfill. The person learning and doing the fix gains a sense of mastery and saves money. It's an unmixed blessing. Stop doomscrolling. Think of what is busted in your house, find the YouTube video on how to fix it, and fix it.

lmao awesome

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57 years ago

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After finally drafting a will, writer Rose Maura Lorre took her end-of-life prep up a notch and got a kit called a Nokbox: a box of worksheets that you file away for any next of kin tasked with managing your earthly to-do’s after you’re gone. Here’s how it went: nytimes.com/wirecutter/rev…