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Chemists from @BaranLabReads report a new stereoretentive radical-radical cross-coupling reaction that enables alkyl–alkyl bond formation while maintaining 80–96% enantiospecificity. Published in @ScienceMagazine, the method works across a wide range of pharmaceutically relevant molecules, offering a useful new tool for drug discovery. More: ow.ly/2Aa750Za5pl
In this month's ChemDev poster by Augustin "Gus" Péneau, we explore the process development behind a campaign to establish a manufacturing route for a topical pan-Trk inhibitor by Neil Stevenson with the BenevolentAI team! Key paper: doi.org/10.1021/acs.op…
We are such a big team, congrats to everyone!!
Final version of this work has appeared today in @ScienceMagazine : science.org/doi/epdf/10.11…
‘Absurd’ radical reaction keeps stereochemistry intact cen.acs.org/synthesis/absu… via @cenmag
If you've noticed electrochemistry showing up in more and more total syntheses, our new review is for you! Electrosynthesis has been around for decades, but its role has only recently taken off – we cover how it went from niche tool to go-to strategy.
Electrochemistry Goes Mainstream: Applications in Modern Total Synthesis, a review appearing today in @ChemRxiv :chemrxiv.org/doi/full/10.26…
Electrochemistry Goes Mainstream: Applications in Modern Total Synthesis, a review appearing today in @ChemRxiv :chemrxiv.org/doi/full/10.26…
A method that enables rapid access to glutarimides has been reported in a collaboration between the Baran Lab and BMS. Glutarimides are a key motif in the TPD (targeted protein degradation) field, and an array of scaffolds beyond those based on substituted thalidomides have entered clinical trials. However, only limited reports of glutarimides bearing α-sp3 hybridized substituents have emerged. In this Chemistry Brief, we highlight a useful extension of the nickel-catalyzed cross-coupling of hydrazides pioneered by the Baran lab and its application to scaffolds relevant to heterobifunctional and molecular glue degraders. Read it on Drug Hunter: drughunters.com/4faHOB5
Congratulations to Scripps Research Professor Jin-Quan Yu, who has been elected to the Fellowship of the @royalsociety, the U.K.’s national academy of sciences, for his pioneering work in synthetic organic chemistry and carbon–hydrogen (C–H) activation research. More: ow.ly/Tr2850Z4Tb5
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Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: chemrxiv.org/doi/full/10.26…
Final version out today in @angew_chem : onlinelibrary.wiley.com/doi/10.1002/an…
3D degraders, enabled by redox-neutral radical cross-coupling, appearing today in @ChemRxiv : chemrxiv.org/doi/full/10.26…. A fabulous collaboration with BMS and the Parker lab.
Congratulations to Scripps Research professor Jin-Quan Yu, who has been elected to @theNASciences, one of the highest honors a scientist can achieve. Recognized for his pioneering work in C-H bond activation, his methodologies simplified the construction and modification of complex molecules, with potential applications in medicine, agriculture and materials science. More: ow.ly/BSr250YRw9H
Published in #AngewandteChemieNovit: A Review of Radical Retrosynthesis of Natural Products Enabled by Iron-Based Reductive Olefin Coupling by Griffin L. Barnes, Alex L. Rerick & Phil S. Baran. Read it here: doi.org/10.1002/anov.7…
Our conidiogenone B total synthesis is hot off the press @J_A_C_S! Cheers! @jo5i3bee @EmoryChem Seven-Step Total Synthesis of Conidiogenone B Enabled by Radical Cyclizations | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
Tungsten Electrochemistry in Organic Synthesis! In our latest @ChemRxiv, we present an exciting collaboration with @Merck @cecibottecchia and @dan_lehnherr An 18-month project carried out by (now Dr.) @n_petrovicc Buckle up, story time! (1/n) chemrxiv.org/doi/full/10.26…
Our latest paper is now out in @J_A_C_S! This study reveals how a seemingly simple change in the supporting electrolyte can reshape the reaction pathway and dictate selectivity in olefin functionalization. Congratulations to the team! pubs.acs.org/doi/10.1021/ja…
A cleaner, scalable approach to build valuable nitrile functionalities using ElectraSyn—no harsh reagents needed. Article👇👇👇 pubs.acs.org/doi/10.1021/ja… #Electrochemistry #OrganicChemistry #Synthesis #GreenChemistry
Out now in @angew_chem : onlinelibrary.wiley.com/doi/abs/10.100…
Radical Retrosynthesis of Natural Products Enabled by Iron-based Reductive Olefin Coupling. Published today in @ChemRxiv : chemrxiv.org/engage/chemrxi…
Great collaboration with @BaranLabReads on a simple 2 step method to complex C-glycosides without protecting groups. @BristolChem
Making C-glycosides SWEET and simple! Today in @ChemRxiv we disclose (chemrxiv.org/doi/full/10.26…), in collaboration with @GroupAggarwal, an incredibly easy way to achieve radical functionalization of sugars. In this video (youtu.be/Fqdbgmx7zEI), a two-step synthesis of the
Angewandte Chemie @angew_chem
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Angewandte Chemie @angew_chem
114K Followers 3K Following Angewandte Chemie, a journal of the German Chemical Society (GDCh, @GDCh_aktuell) - a leading journal in #chemistry published by @WileyGlobal in @Weinheim
J. Am. Chem. Soc. @J_A_C_S
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Total Synthesis @TotalSynthesis
18K Followers 1K Following @SoufianTibouti thinks Nature is the ultimate chemist.
MaulideGroup @MaulideLab
17K Followers 445 Following Research group based in Vienna. Organic synthesis and methodology
Yulab @YulabJin
13K Followers 571 Following breaking one CH bond per day...keeping headaches away...
Engle Lab @EngleLab
11K Followers 205 Following catalysis, reaction discovery, and samoyed sled racing @scrippsresearch. views our own.
Cornellab @CornellaLab
13K Followers 1K Following Synthesis focused. Catalysis driven. At Max-Planck-Institut für Kohlenforschung
Jake Yeston @JakeYeston
9K Followers 3K Following Editor @sciencemagazine, left this God-forsaken site for bluer pastures (https://t.co/EPRofYnUOm)
Stuart Schreiber @SchreiberStuart
18K Followers 381 Following Truth-seeking scientist; equal parts Cajun, Mississippian, Irish, Hungarian.
Kevin Lam @KLchemistry
6K Followers 2K Following Professor of Synthetic Electrochemistry - University of Greenwich! find me on https://t.co/Jc496qAa3z ⚡️ . Views are my own.
Synthesis Workshop @MatthewHorwitz1
8K Followers 850 Following Synthesis Workshop is a video podcast exploring the frontiers of synthetic organic chemistry created by Matt Horwitz, Ph.D. https://t.co/iB4pKXqHuX
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drug hunter @drughunter_com
11K Followers 26 Following the science of drug discovery, distilled for industry innovators. discover more by subscribing at: https://t.co/FnfsOmSXe4
Gabriele Laudadio @g_laudadio
3K Followers 861 Following Organic Chemist, Group Leader E-Chem Team @UniGraz | Postdoc at @BaranLabReads | PhD in @NoelGroupUvA. 2022 #CASFutureLeader, 2021 #RealTimeChem Ambassador.
Laszlo Kurti @kurtilaszlo
6K Followers 2K Following The Kürti group at Rice University focuses on the development of direct C-N, C-O and C-C bond-forming methods that are both simple and scalable.
Jacobsen Lab @JacobsenLab
5K Followers 116 Following Student-run Twitter account for the Jacobsen Group @HarvardCCB | Tweets by Eric signed ENJ
Joseph Derosa @JDerosaChem
1K Followers 751 Following Assistant Professor @BUChemistry | Member of @derosalab | transition metal and (electro)catalysis enthusiast | NYC born and raised
Christian Malapit @CAMalapit
3K Followers 1K Following Asst Prof of Chemistry @NorthwesternU | Organic electrosynthesis, organometallic catalysis, energy storage | 🇵🇭 scientist | PI of @MalapitLab
Knight Chemicals @knight_chem
39 Followers 134 Following High-quality building blocks & custom synthesis for drug discovery. Tier 1 delivery. Run by chemists. Built for innovation.
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76K Followers 39 Following Official account of Jay Bhattacharya, the 18th @NIH Director. Privacy: https://t.co/pcNDp62J5S
David Cagan @cagan_da
477 Followers 439 Following @NSF Postdoctoral Fellow in @BaranLabReads, @ScrippsResearch | PhD in Hadt Lab, @CaltechCCE | @theNASEM Ford & @NSF GRFP Fellow | Founder of Caltech Rising Tide
Yuzhong Liu @Liulabscripps
519 Followers 314 Following Assistant Professor in Chemistry at Scripps Research, La Jolla
Sarah Gillis @Gillis_SarahE
24K Followers 257 Following Mission Specialist on Polaris Dawn. CU Boulder graduate, coffee addict, avid hiker and adventurer!
World Laureates Forum @wlaforum
35K Followers 397 Following The WLA promotes basic science, advocates for international cooperation & supports the development of youth. FB: https://t.co/BcAcBAjaen WLA Prize @thewlaprize
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158 Followers 98 Following Helping academic organizations improve academic integrity with the best plagiarism detection service
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Li Ye @liye_tsri
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252 Followers 449 Following Assistant Professor at Shanghai Jiao Tong University. Research focus on oligo nucleotides & organic synthesis.
Ardem Patapoutian @ardemp
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Winssinger @WinssingerLab
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