Sean Rogers @BiochemSean
Postdoc in @Pagliarini_Lab studying mitochondrial lipids; PhD in @hennelab; interested in cellular organization and metabolism Dallas, TX Joined March 2021-
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Following319
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Sean Rogers retweeted
Wonderful to see our paper on regulation of the #Organelle #ContactSite #NVJ out in its final form in @J_Cell_Sci! Congratulations to first author @MarieHugenroth and the whole team! journals.biologists.com/jcs/article/13…
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Sean Rogers retweeted
As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime doi.org/10.1038/s41594…
@MikeLangePhD @LeventalLab @OlzmannLab Congrats Mike, fascinating work!
Sean Rogers retweeted
Now published, @SHUBHAM30642626 identifies PLD3/4 as synthesizing BMP, a lipid crucial for #lysosome #lipid #metabolism and #brain health sciencedirect.com/science/articl…
Sean Rogers retweeted
CoQ10 is a very hydrophobic molecule with poor bioavailability. In this new study, led by @LauraSteenberge, we build on prior work to show that the much more soluble CoQ4 is sufficient to rescue diverse CoQ functions and can be targeted to mitochondria. doi.org/10.1016/j.jbc.…
Sean Rogers retweeted
Happy to share this little 'In a Nutshell' highlighting work from @ButtnerLab, @MariaBohnert, & our own @naaatalieortiz. We discuss yeast lipid droplet subpopulations & the proteins that license them for tasks. Also discuss lipid ordering @ vacuoles. doi.org/10.1002/1873-3…
Sean Rogers retweeted
We are so proud to share the final version of our latest #MembraneContactSites story🎉, now in @Dev_Cell. We identify the LDO proteins and Vac8 as a tethering pair between the vacuole and lipid droplets (vCLIP) that mediates microlipophagy in starvation cell.com/developmental-…
Sean Rogers retweeted
Really exciting work in @Nature on role of 7-dehydrocholesterol (7-DHC) in the suppression of ferroptosis. nature.com/articles/s4158…
Sean Rogers retweeted
biorxiv.org/content/10.110… I am thrilled to see our pre-print out and available to the scientific community. Co-led by @AbbyBartlett_, we identify two mammalian enzymes that drive the catabolism of 4-hydroxy acids through FAO via 4-phosphoacyl-CoA intermediates. #lipids #metabolism
Sean Rogers retweeted
Extremely proud of grad student @naaatalieortiz! See her paper, now out in @JCellBiol, where she characterizes a regulator of lipolysis that decorates TG-rich LDs. rupress.org/jcb/article/22…
Sean Rogers retweeted
Excited to share our new discovery of a mitochondrial isoprene transporter published today in @NatureCellBio and led by @mitojondrion! Interesting example of transporter dual functionality. #Mitochondria nature.com/articles/s4155…
Sean Rogers retweeted
Preprint alert! We are happy to introduce Contact-FP, a suite of probes for studying #MembraneContactSite dynamics. This was an amazing team effort led by Research Associate @GregoryMiner18 and postbacc Sidney Smith 1/11 biorxiv.org/content/10.110…
Sean Rogers retweeted
Everything you always wanted to know about the mitochondrial proteome but were too afraid to ask. From classic enzymology to novel mass spectrometry techniques. I'm so happy to finally have this out there!
Happy to share our new mitochondrial proteome research review out today in @NatRevMCB led by @Zak_Bakes and @PatrickForny. The field has come a long way in the past 20 years, yet plenty of exciting new things to do! nature.com/articles/s4158… rdcu.be/dnmm3 #Mitochondria
Sean Rogers retweeted
“Fortune favors the prepared mind.” We @abu_remaileh and team serendipitously discover that CLN5, a genetic risk factor for Alzheimer’s disease, encodes the long-sought bis(monoacylglycero)phosphate synthase (BMPS) published in @ScienceMagazine. (1/11) science.org/doi/10.1126/sc…
Sean Rogers retweeted
Updated preprint! Led by @natalieortiz in collaboration with Jessica Swanson, we characterize protein Tld1 (Triglyceride-associated Lipid Droplet protein 1) and show it preferentially localizes to Triglyceride-rich LDs and regulates lipolysis. doi.org/10.1101/2023.0…
Sean Rogers retweeted
I’m excited to finally share this project from the @TJ_MeliaLab where we demonstrate that the lipid transport protein ATG2 is active and highly efficient on phospholipid monolayers. (1/3) biorxiv.org/content/10.110…
Sean Rogers retweeted
CoQ10 is large and very hydrophobic, which limits its bioavailability. Our new study, led by @LauraSteenberge, shows that CoQ4 is a sufficient substitute for multiple CoQ functions in cells and can be targeted to mitochondria. biorxiv.org/content/10.110… #bioRxiv #mitochondria #CoQ
@hanahariri @WayneStateCLAS @WSUBioSci Congratulations Hanaa, much deserved!
Sean Rogers retweeted
Happy to have this little review out in Current Opinion in Cell Biology. #cellbiology Interested in the (social) lives, deaths, and biophysical phases of lipid droplets? Check out our short review/commentary on these remarkable organelles. authors.elsevier.com/a/1hD4p3PA3sV0…
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