Andrew Brack @BrackLab

Scientist interested in preventing functional decline during aging. Program Manager at ARPA-H. Interests: Crypto, Everton FC and Boxing. Views are my own. CA Joined April 2012

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Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1

13 hours ago

I remember exploring what could be pulled from NHANES during my PhD days. The data keep getting richer, and NCHS open access resources remain underutilized. That said, it’s critical to account for the limitations of serial cross-sectional data. True cohort studies, and especially RCTs, are essential for disentangling causality.

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Andrew Brack @BrackLab

11 hours ago

How do we tell whether a drug helps people function better and stay independent longer as they age? We think Intrinsic Capacity is a promising place to start. We recently shared our @ARPA_H-led consensus framework at the @reaganudall meeting with @US_FDA regulators. We are calling on researchers and trialists to build evidence for the use of IC across trials. Here's the link to the full document origin.arpa-h.gov/sites/default/… and a one pager for the key takeaways.

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Andrew Brack @BrackLab

5 days ago

Interesting take. My only concern is that cross sectional data will only give us a predictive average for a population. NHANES is a valuable dataset but without longitudinal data you might not get high prediction for something like aging that has heterogenous trajectories.

Longevity Science Podcast @longevityscipod

a week ago

Democratizing longevity is now possible! This approach is affordable to measure, using biomarkers from NHANES. By revising the algorithm to reduce costs while maintaining predictive accuracy and personalization, we unlock true value in longevity.

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Longevity Science Podcast @longevityscipod

a week ago

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Andrew Brack @BrackLab

5 days ago

I’m in DC for @ARPA_H home week. It’s a beautiful day. Took a moment to see what’s being built on the White House lawn.

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Andrew Brack @BrackLab

5 days ago

@m_goes_distance What’s your fund size?

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Michelle Kwok 💫 @michellebkwok

a week ago

Most VC is just asset management with better branding. The 15th productivity SaaS. The third food delivery app. Consensus investing in whatever already worked last cycle. This year we backed a company turning 55-year-old stem cells back to their embryonic state. Another that vaporizes tumors without making a single incision. One reprogramming cells like software to cure disease instead of just managing symptoms. A brain-computer interface restoring motion to amputees. Every single one sounded impossible until it wasn't. The science is out there. Sitting in labs, underfunded, waiting for someone with the conviction to get behind it. The job isn’t just writing a check, it’s also believing when almost nobody else does. That's what VC looks like when it's aimed correctly. Simply civilizational upside. What's the most important science you think is criminally underfunded right now?

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Andrew Brack @BrackLab

a week ago

The pie is getting bigger

STAT @statnews

a week ago

Longevity startup NewLimit raises $435 million ahead of first clinical trial trib.al/KpM8SiJ

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Andrew Brack @BrackLab

a week ago

@CharlesMBrenner Enjoy the adventure

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Core Memory @corememory

a week ago

Go on. Look at these mice!!!! They're old and hungover but cruising around like it ain't no thang. NewLimit appears to have a therapy that reverses short and longterm damage from booze. Just remarkable results, heading to human trials next year. We get into it all on the latest Core Memory podcast with Jacob Kimmel, the co-founder and president of NewLimit.

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Insilico Medicine @InSilicoMeds

a week ago

The Unexpected Challenge of Hiring "Experienced" AI Pharma Talent "Many experienced hires have been living in a bubble and got used to being unproductive." In AI drug discovery, the real gap isn't credentials, it's the ability to actually produce. We don't need more press releases or research papers; we need drugs that work. It's time to burst the "unproductive bubble." #AlexZhavoronkov #InvestingTips #PharmaAI #BiotechReality #VentureCapital

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Andrew Brack @BrackLab

a week ago

@jacobkimmel @newlimit @foundersfund @ThriveCapital @Greenoaks Awesome @jacobkimmel. Wonderful news

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Andrew Brack @BrackLab

2 weeks ago

Couldn’t agree more, PROSPR🖖

Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1

2 weeks ago

"Live Long and Prosper" 🖖 Wonderful seeing Jose @cordeiro at the Berlin Life Summit before his longevity advocacy work at the European Parliament. To aid his mission, I gave him a copy of the Harvard Special Report on Longevity, a project I proudly served as medical editor for.

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Max Unfried @MaxUnfried

2 weeks ago

Interested in Entropy & Aging? Note that there will be an Entropy in Aging conference and workshop in Cologne end of August, enabled by the International Aging Entropy Open Research Network! Attendance is free of charge and focused on intimate discussions! sites.google.com/view/entropyin… @Meyer_DH

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Andrew Brack @BrackLab

2 weeks ago

@agingdoc1 Well done David

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Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1

2 weeks ago

It’s here🌟 I served as Medical Editor for this 50-page report, to bring rigorous, evidence-based longevity science to a broad general audience. Grateful to have contributed, excited to see the longevity conversation move further into the mainstream👇 🔗linkedin.com/feed/update/ur…

Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1

2 weeks ago

Tweet 1: Harvard Medical School has just published its first-ever Special Health Report on Longevity. I served as Medical Editor. The first time an institution at this level has done a comprehensive treatment of longevity science for a mass audience. Full announcement:

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Patrick Collison @patrickc

6 months ago

Two conversations this weekend make me think that there's a vibe shift afoot in Silicon Valley around what one should work on and what is worthwhile. Culturally, it feels like the moment is ripe for new frameworks: • Davos expert morality is stale and discredited. • It's also apparent that the "just be super based" Counter-Enlightenment is not really an answer. (Yes, woke went too far, but simply inverting it doesn't work.) • EA is no longer the automatic default for smart people. • There's increasing skepticism of slot and slop machine dynamics. Overall, "what is worthy and valuable?" feels like it's becoming more central.

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Andrew Brack @BrackLab

2 weeks ago

@MartinBJensen Time will tell, but it felt different.

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Andrew Brack @BrackLab

2 weeks ago

I was honored to be involved in this important discussion on the clinical and regulatory path for gerotherapeutics. @ARPA_H, @reaganudall and @xprize. Thankyou to our @HHSGov colleagues at @US_FDA for your contribution.

Foundation for FDA @reaganudall

2 weeks ago

.@US_FDA Chief Scientist Dr. Steven Kozlowski provides opening remarks during our hybrid public meeting on Affecting the Aging Trajectory: Regulatory Constructs for Gerotheraeputic Drug, Biologic & Device Development.