Devin Bendixsen, PhD @DevinBendixsen
Research Fellow | Harvard Medical School | Department of Genetics | Bioinformatics | Cancer Genomics naxerova.hms.harvard.edu Boston, MA, USA Joined November 2018-
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We have a new paper out in Molecular Ecology, led by @DevinBendixsen ! Reproductive isolation due to divergent ecological selection is accompanied by vast genomic instability in experimentally evolved yeast populations onlinelibrary.wiley.com/doi/10.1111/me…
Thrilled to see #SAVANA out in @naturemethods🥳 SAVANA detects haplotype-resolved somatic SVs and copy number aberrations (SCNAs) and infers tumour purity & ploidy in clinical samples using long-read sequencing with or WITHOUT a matched germline control 👇nature.com/articles/s4159…
Interested in the mysteries surrounding metastasis evolution? This perspective in @NatureRevCancer is my best attempt at proposing a framework that could help advance our thinking about the topic. Well. At least it helped advance my own thinking. 😅 nature.com/articles/s4156…
We have a 4-year fully funded PhD position available! su.varbi.com/en/what:job/jo…
And now, we also have a 2-year postdoc position in the Stelkens Lab! 🧪 If you are interested in parallel evolution, genomics, yeast, and climate adaptation, this could be for you! Please apply through U Stockholm's job platform here: su.varbi.com/en/what:job/jo…
🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” biorxiv.org/content/10.110… [1/12]
Happy Holidays from the Bendixsen Clan!
I'm proud to share that our article has been published in @NatureComms Our findings reveal fascinating patterns, explained by a theoretical model proposed over 100 years ago by the legendary J.B.S. #Haldane ⭐️ #Hybridization #Adaptation #Evolution
Hybrids have complex genomes that influence their adaptive potential. Bautista et al. show that yeast hybrids adapt slower than their parental species, primarily due to a reduced rate of loss of heterozygosity in key genes @CarlaBautistaRo @LandryChristian nature.com/articles/s4146…
Hybrids have complex genomes that influence their adaptive potential. Bautista et al. show that yeast hybrids adapt slower than their parental species, primarily due to a reduced rate of loss of heterozygosity in key genes @CarlaBautistaRo @LandryChristian nature.com/articles/s4146…
Exciting demonstration of the value of deep WGS, and calling of structural variants, for effective patient stratification
Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer biorxiv.org/cgi/content/sh… #biorxiv_cancer
High grade serous ovarian cancer (HGSOC) is an exemplar tumour type for studying chromosomal instability. I'm delighted finally to share with you our efforts to disentangle the chaos from the underlying biology... biorxiv.org/content/10.110… 1/
The pretty version of our paper in @MolBioEvol is out! "The Dynamics of Adaptation to Stress from Standing Genetic Variation and de novo Mutations" explores the result of ~1000 gens of baker's yeast evolution in the lab 🧪! 1/n #ExperimentalEvolution academic.oup.com/mbe/article/39…
Don't know for how long I haven't seen a paper in actual print. Look, @DevinBendixsen! Check out the cute yeast cartoon open access here tinyurl.com/ycxm4zhv in @ELS_Genetics 👹
Proud to report that our paper on 'The dynamics of adaptation to stress from standing genetic variation and de novo mutations' is accepted for open access publication in Molecular Biology and Evolution @MolBioEvol. Pdf here (pretty version will follow) doi.org/10.1093/molbev…
New preprint out by @StelkensLab on the 'dynamics of adaptation to stress' using E&R. Beautiful work by PhD student @CiaranGilchrist and postdoc @LoreAment & other lab members. So excited since this has been in the making for 5 years! So much for yeast is a fast system. 😉
The Stelkens Lab is looking for a #postdoc in #yeast evolution and genomics! Start date asap. 2-year period with possible extension. Project is flexible but should involve experimental evolution, #Saccharomyces, and fundamental questions in evolutionary biology. Come join us!
Our opinion paper on the evolutionary and ecological potential of yeast hybrids with @DevinBendixsen is out! doi.org/10.1016/j.gde.…
New paper alert! Heads up, if you are interested in lineage tracking with DNA barcodes. This is Shepherd, an accurate new clustering method to reduce noise and distinguish true from error sequences academic.oup.com/bioinformatics…
In "Saccharomyces #yeast hybrids on the rise," authors @DevinBendixsen, João G. Frazão & @StelkensLab present new numbers on genomes sequenced, assemblies, annotations, & sequencing runs + more. Read it in @Yeast_Journal. 🔗 ow.ly/v0gg50HHXnL
In "Saccharomyces #yeast hybrids on the rise," authors @DevinBendixsen, João G. Frazão & @StelkensLab present new numbers on genomes sequenced, assemblies, annotations, & sequencing runs + more. Read it in @Yeast_Journal. 🔗 ow.ly/V3cK50HHX5i
Join us at Stockholm University, we have a postdoc position available in evolutionary genomics. Don't let the application criteria deter you, we want to hear from you! Deadline is 15 Jan #yeast #genomics #evolution
We have a postdoc position available! Apply if you are an evolutionary biologist interested in the genetics of adaptation and experimental evolution with yeast! #saccharomyces #popgen #genomics #experimentalevolution
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