Divagar Thirumoorthy @Divagar1998
Singapore Joined March 2014-
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Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The problem with CRISPR is that it cuts up your DNA, and then hopes that unreliable cellular DNA repair will make the wanted edit. @geochurch famously called it genome vandalism. More precise versions of CRISPR only edit less than 100 bases - often only a single base. Therefore, it's not suited to make large changes safely. However, most diseases are not the result of mutations in one location. Instead, their causes are spread all across the 3 billion base pairs in the genome. We found bridge RNAs in bacterial “jumping genes” that allow us to make safe and arbitrary changes (insert, cut out, or flip) to every nucleotide within (up to) a 1 million bp sequence in your DNA. In the paper, we show that we can correct the disease-causing DNA repeats that cause Friedreich's ataxia (which is a rare neurological disease). The same approach could be applied to Huntington’s and other repeat expansion disorders. At @arcinstitute, we're working towards a full Turing machine for biology. Evo, our DNA foundation model, helps us design the optimal healthy DNA sequences. And Bridge recombination gives us the ability to seamlessly write these changes into the right place in the genome. This work was a wonderful collaboration with my @arcinstitute cofounder @SKonermann and led by the indefatigable @ntperry13, alongside our amazing bridge editing team: @BartieLiam @dhruvakatrekar @Gabogonzalez515 @mgdurrant @james_jw_pai @AlisonFanton Juliana Martins Masa Hiraizumi @chiaroscurale @hnisimasu
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
1/11 Our study on subclonal immune evasion in non-small cell lung cancer has just been published in @Cancer_Cell cell.com/cancer-cell/fu…
"Here we present the first direct evidence that H3K4me3 is not a cause but a consequence of transcriptional activation, functioning as a downstream epigenetic response" biorxiv.org/content/10.110…
1) Since there is a lot of confusion about the reduction of the overhead rate on NIH grants to 15% (see here: grants.nih.gov/grants/guide/n…) I'll do a little tweetorial (or X-torial?) about it.
Do not use your energy to worry. Life is too short to worry about stupid things. Have fun. Fall in love. Regret nothing, and don't let people bring you down. Study, think, create, and grow. Teach yourself and teach others.
@kaushikilango Needed to hear this today
@paulgabrail @AswathDamodaran @EMoneyYouTube @realmostafah Hyped for this!
@paulgabrail @paulgabrail What is your opinion on Fitch’s downgrade of the US? Was hoping for a video about this on Everything Money
@Investmentkage I guess it would be troublesome to keep factoring in depreciation
@kaushikilango Hmm what’s the rationale
@kaushikilango Is b) a typo? Surely you mean “polygamy”
@kaushikilango Though I wouldn’t say it’s necessarily true right? In the case of SR or brahmacharya or even going on a diet etc…
@Smartnetworth1 @whitby111 Ah I see makes sense
@Smartnetworth1 @whitby111 What were the reasons behind your decision?
@Smartnetworth1 @whitby111 I’d like to ask what’s your opinion on Intel, I’m long in Intel with an average price around $40 and am reconsidering my position
@paulgabrail Dear Mr Gabrail, I’ve been following your YouTube channel religiously for a year. I am happy to see a variety of companies being covered, though I’m curious as to why major banks companies are not. Could it be that you avoid bank stocks for a particular reason? Curious…
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US Inflation Rate (CPI), YoY % Change... Jun 2022: 9.1% Jul 2022: 8.5% Aug 2022: 8.3% Sep 2022: 8.2% Oct 2022: 7.7% Nov 2022: 7.1% Dec 2022: 6.5% Jan 2023: 6.4% Feb 2023: 6.0% Mar 2023: 5.0% Apr 2023: 4.9% May 2023: 4.0% Jun 2023: 3.0% 12 consecutive declines.
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11K Followers 65 Following 400K+ YT subs. Instagram: paulgabrail --- Chess is my flex. Stonks. 1000+ units owned. "Bitcoin is a f**king scam!" - Me on HBO DocumentaryTrends for United States
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