Genomics Proteomics Bioinformatics @GPBees
A prestigious journal for omics and bioinformatics areas. 20 years of excellence since 2003. academic.oup.com/gpb Beijing Joined January 2020-
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A GPB study employs spatial ATAC-seq to construct chromatin accessibility landscapes in breast cancer, revealing three cross-patient functional modules and two spatial subclones with divergent epigenetic profiles that correlate with patient prognosis. doi.org/10.1093/gpbjnl…
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A GPB study presents a single-cell transcriptomic atlas of the mouse thymus, revealing age-related decline of CD8+ T cells and Smad4/Smad7, and dendritic cell–DP-2 T cell interactions via MHC-II that promote T cell development. doi.org/10.1093/gpbjnl…
A GPB study introduces wellDR-seq, a Nanowell-based method for direct co-sequencing of CNAs and transcriptomes in single cells, revealing ancestral subclones, epithelial lineages, and gene dosage effects in ER+ breast cancer. @Ruli_Gao doi.org/10.1093/gpbjnl…
A GPB study introduces MetaDIA, a DDA-free database reduction strategy for DIA gut metaproteomics, which leverages taxonomic abundance and peptide detectability to drastically shrink search space while maintaining DDA-library-level accuracy. doi.org/10.1093/gpbjnl…
A GPB study about urinary proteomics biological basis, analytical strategies, DDA/DIA roles, cross-disease signatures, and AI-driven multi-omics integration toward precision medicine. doi.org/10.1093/gpbjnl…
A GPB study introduces a protein language model (MPCutter) to predict protease-specific substrate cleavage sites. doi.org/10.1093/gpbjnl…
Genomics Proteomics Bioinformatics retweeted
Excited to share that our collaborative work with Prof. Chuan He’s team at the University of Chicago that developed the first spatial RNA modification sequencing technology (m6A-ARTR-DBiT) has been published in @naturemethods 🥳🥳 nature.com/articles/s4159…
Genomics Proteomics Bioinformatics retweeted
Nature research paper: αKG-mediated carnitine synthesis drives DNA repair via histone acetylation go.nature.com/4wOc9vv
Genomics Proteomics Bioinformatics retweeted
Nature research paper: Cold-induced peptide signalling secures pollen resilience and crop yield go.nature.com/4x5kCKY
A GPB study about in situ multi-omics system that reveals bacterial cell symbiosis and development in deep-sea mussels doi.org/10.1093/gpbjnl… mp.weixin.qq.com/s/NgNIula7JROA…
Genomics Proteomics Bioinformatics retweeted
Artificial intelligence is not replacing human intuition in maths and physics, but reimagining how questions are asked, explored and understood go.nature.com/4vG4Vsl
Genomics Proteomics Bioinformatics retweeted
Researchers say they have used a precise genome-editing technique called base editing to alter the genome of human embryos for the first time go.nature.com/3RLdK5v
A GPB study expands the "ubiquitin code," revealing how atypical K6 ubiquitin chains regulate serine uptake, transporter endocytosis, and nutrient sensing via the Tor1-Npr1-Par32-Gnp1 axis. doi.org/10.1093/gpbjnl…
A GPB study mapped a pan-cancer eRNA atlas linking hallmarks and networks. In hepatocellular carcinoma, ADAMTS5e drives metastasis and sorafenib resistance, advancing precision oncology. doi.org/10.1093/gpbjnl…
Genomics Proteomics Bioinformatics retweeted
What is the global structure of cell-state space—and how do perturbations drive transitions within it? Excited to share our new preprint (biorxiv.org/content/10.648…), a work in collaboration with @JswLab.
⛰️ A #GPB study reveals ITGA2B as a key regulator of high-altitude myocardial injury through effects on inflammation, mitochondrial function, and glycolysis under hypoxia. The work also identifies tanshinone IIA as a potential therapeutic strategy. doi.org/10.1093/gpbjnl…
Genomics Proteomics Bioinformatics retweeted
Excited to share my first postdoc work co-led with Yuichi Chayama, from @andcyang lab - now out in @CellCellPress! We created a genetic system to trace how the brain clears waste, uncovering surprising new biology about waste clearance pathways. 🧵1/9 🔗 cell.com/cell/fulltext/…
Genomics Proteomics Bioinformatics retweeted
Damage-induced i-loops generate eccDNA from repetitive elements dlvr.it/TShFCD
🧪 A #GPB review highlights MS-based solutions for single-cell proteomics, covering advances in single-cell isolation, sample preparation, LC-MS, and bioinformatics. doi.org/10.1093/gpbjnl… #SingleCell #Proteomics #MassSpectrometry
Key updates include reannotation of released prokaryotic genomes, mirroring of NCBI GenBank and RefSeq resources, integration of Poxviridae sequences, online batch submission, upgraded quality control, advanced search, and controlled access for human genome data.
🧬 The updated Genome Warehouse (#GWH) continues to enhance the value, security, and usability of genome data. @heatingtube Welcome to visit GWH: ngdc.cncb.ac.cn/gwh #Genomics #GenomeData #Bioinformatics #Database
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