Hugo Farne 🫁 @HugoResp
Respiratory 🫁 doctor. Specialist interest in asthma London, England Joined January 2013-
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Following517
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@HMRCcustomers if one receives a giro credit for a tax refund & it expires before it is deposited (not many banks have counters to accept these), how do you get one reissued (or a bank transfer instead)? Online assistant suggests calling. After 1h, phone assistant says online 🤯
@HMRCcustomers Self assessment tax refund
Hugo Farne 🫁 retweeted
This study validates a previously reported bronchial signature of bronchiectasis in nasal epithelium. Changes in gene expression and cell-type composition associated with radiological bronchiectasis are similar across both bronchial and nasal epithelia. bit.ly/4qgq7SO
Hugo Farne 🫁 retweeted
European Respiratory Journal: TSC2 mutations are the main cause of sporadic LAM in nearly all patients bit.ly/4rZoqtJ
Hugo Farne 🫁 retweeted
Inhaled anti-TSLP for persistent asthma -Phase 1 study linkinghub.elsevier.com/retrieve/pii/S… AZD8630 well tolerated with low incidence of ADA Suppression of FeNO indicating effects on airway epithelial cells and downstream IL13 signalling
Hugo Farne 🫁 retweeted
Excited to share our ‘Evolutionary characterization of #LungCancer metastasis’ in #TRACERx & #PEACE, published today in @Nature: a decade spanning effort led by the Jamal-Hanjani lab, @SwantonLab, @NickyMcGranahan & @ZaccaSimo at @uclcancer & @TheCrick. Link below
@ProfJDChalmers What about patients not eligible eg non-eosinophilic - what’s in the pipeline for them? And are there any plans to trial DPP1 inhibitors in COPD? (Question for both you and Mona!)
@ProfJDChalmers How do we ensure we select the right patients to see the benefit seen in trials - and ensure we can continue to prescribe these drugs? 2/
@ProfJDChalmers Very nice work! Azurocidin-1 also elevated in some patients with asthma. I wonder if DPP1 inhibitors might be effective in airways disease, if we can appropriately select patients?
Hugo Farne 🫁 retweeted
A study 10 years in the making, just published in @LancetRespirMed How do DPP1 inhibitors really work in bronchiectasis? We show a novel mechanism for treatment efficacy, by inhibiting Azurocidin-1, a ciliotoxin, DPP1i can enhance mucociliary clearance. thelancet.com/journals/lanre…
Hugo Farne 🫁 retweeted
ECCMID 2026 No induction of resistance over 6 months with monoclonal antibody therapy against pseudomonas in bronchiectasis Encouraging beneficial changes to the microbiome too Encouraging early results presented by @beccahull_
Hugo Farne 🫁 retweeted
Inhaled immunoglobulin as a novel treatment for bronchiectasis: results from a phase 1 trial Inhaled immunoglobulin G was associated with low rates of adverse events and reduced airway bacterial burden. Encouraging results! Online now at @ATSBlueEditor academic.oup.com/ajrccm/advance…
Hugo Farne 🫁 retweeted
People often ask how breakthroughs occur in cancer biology-often the story is more complex - the survival plot for myeloma outcomes is extraordinary - improvements come about in incremental steps - in my lifetime treatment of Myeloma has almost transformed into a curable disease
Hugo Farne 🫁 retweeted
No cigar for Rilzabrutinib (BTK inhibitor) in mod-sev asthma (Ph 2) Futility on primary EP of loss of asthma control upon withdawal of ICS/LABA thelancet.com/journals/lanre…
It makes no sense to me to close roads and dig them up just before a 4 day bank holiday with the disruption inevitably being extended by 4 more days? @MayorofLondon can you make it prohibitively expensive to do this? @CadentGasLtd @UKPowerNetworks @thameswater
Hugo Farne 🫁 retweeted
Just counting blood vessels on #CT of #COPD pts predict lung function and its decline, exercise capacity & symptoms; better imaging biomarker of disease burden in #COPD than anything else we have bit.ly/4qe73W6
I suspect it is easier signing up for locum agencies - which are more costly for Trusts and by extension, taxpayers. 2/
@DHSCgovuk @wesstreeting Resident doctor strikes have highlighted all sorts of issues. Not least the inefficient process to sign up to the bank to locum. Why do occupational health checks have to be in person? And why can’t in person ID checks be at the nearest hospital HR? 1/
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