Kawate lab @KawateLab
We💙membrane proteins! Using biochem, structural bio & C.elegans to study cell-cell communication, physiology & behavior, pain sensing & more @cornellmolmed kawatelab.org Ithaca, NY Joined October 2021-
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This study puts forth a mechanism by which c-terminal cleavage liberates the CAD causing the repositioning of the N terminus to promote Panx1 channel opening.
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Our structural studies revealed that when exposed, the cytoplasmic domain, dubbed the c-terminal activating domain (CAD) can compete with the N-terminus to occupy a cytosolic pocket, which forces the N-terminus to reorient into the pore.
Could not be more exciting to share our latest findings about the mechanism of ATP release via the Pannexin 1 ion channel! Check it out 👉 The C-terminal activating domain promotes pannexin 1 channel opening | PNAS pnas.org/doi/10.1073/pn…
We analyzed the electrostatic free energy of the cytosolic NTD, finding a positively charged region inside the pore that could accumulate negatively charged anions like ATP. In the reoriented NTD conformation this negative region is diminished reducing accumulation of ions there.
@guntherwho @CornellMolMed @KeyenceUSA Incredible addition.
Kawate lab retweeted
When nematodes become nemaTUBE holders 🪱🧪 (thanks for the nematode @korethegenius and the pun @jacqueline_ehr !)
🚨🚨check it out!! We got 3D models of our C.elegans localization studies!! 🪱@sarahkcodd
Happy #InternationalWomansDay!! An official welcome to our #girlslab @ktcrow11 👩🔬👩🔬👩🔬
Congrats to our department-mates! We’ve been eagerly following this story at our @CornellMolMed seminars & so excited to see it out!
Check out our latest paper about glutaminase filament on @NatureComms! In this paper, we used #CryoEM and light scattering to show that the filament formation of glutaminase is coupled with its activity. nature.com/articles/s4146…
Kawate lab retweeted
Its #LabFeatureFriday! Head over to our LinkedIn to learn more about Graduate Student @jacqueline_ehr and her work in the @KawateLab here at @cornellvet bit.ly/3OQlej5
We got our Philly (fill-y lol) ! Always a pleasure to share our work with the #BPS community. Headed back to 📍Ith feeling inspired & refreshed 💆♀️
Kawate lab is en route to #BPS2024! Let’s talk about Pannexins at Toshi’s platform session on Tuesday & @jacqueline_ehr poster presentation on Monday 🤜🤛
Kawate lab retweeted
Hear me out … a jewelry store that sells diamonds in the shape of your protein crystals
Kawate lab retweeted
Ran across this in my rotation students notes … I guess I really emphasized it🤔
Kawate lab retweeted
Kawate lab retweeted
Sometimes you have to purify proteins late on Friday night and sometimes your coworkers turn it into a pizza and dance party 🫶
Kawate lab retweeted
It looks like my proteins are having a meeting in the middle of my grid … a macromolecular assembly if you will
#NewProfilePic Our new logo makes its debut! Can anyone identify the membrane protein that Toshi used as his design inspiration??
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