Prague TRP lab @LabTrp
Prague Joined November 2019-
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Khan et al. study the mechanisms by which TRPA1 channels contribute to mechanical and cold hypersensitivity, and show that the scaffold protein IQGAP1 is an essential part of this process. bit.ly/3PtaOFj
It was an absolute pleasure to measure the TRPV2! After years with TRPA1, which has its moods, recent experiences with TRPC5, which lives its own life regardless of the investigator's efforts, measuring a well-behaved TRPV2 was a refreshing experience. rdcu.be/c05YD
Fellow adventurers on a quest to tame pain please note: Our article on TRPC5 and duloxetine has just been featured on Medicine Innovates. medicineinnovates.com/molecular-targ…
🚨 Job alert 🚨 We have a open position for a PhD candidate at the @soehnleinlab !🔬DM me for more project info and apply at jobs-sf.ukmuenster.de/job/UKM-Wissen… we are look forward to get to know and work with you. Please retweet 😃 @UK_Muenster awaits you! (GUV to bring attention 😁)
The hours spent on single channel analysis paid off. Our paper characterizing the #ColdSensitivity of #TRPC5 #ionchannels has just been published. doi.org/10.1002/jcp.30…
@RSBon_Lab Thanks Robin. To our surprise, Elsevier was faster than Wiley and the duloxetine story is out before the cold sensitivity paper.
In our lab, two years ago... A: There's a drug that relieves cold-induced pain, but it's not known why... B: Let's see if it modulates TRPC5 - it should be cold-sensitive... The article's out, see for yourself. sciencedirect.com/science/articl…
A Special Issue on #TRPA1 Channel is open for submission: mdpi.com/si/53959 #mdpiijms via @IJMS_MDPI
Phosphorylation switch off on #TRPA1? mdpi.com/871446 via @MDPIOpenAccess Found by our student Tyna during her master’s degree. Check the story and do not forget that the special issue of IJMS about TRPA1 is still open for contributions! mdpi.com/journal/ijms/s…
Excellent review on chemical biology tools for studying #ionchannels by @LabPless @laninja2744 @UCPH_health Read it now 👉 buff.ly/35s32EU
My lab is looking for new post doctoral fellows (fully funded) interested in focusing on the intersection of RNA biology and chromosomal regulation in the immune, neural or any other interesting biology of their choice. Thanks much for RT.
Presenting cryoEM structures of full-length Glycine receptor in lipid membrane, now out in @NatureComms We had exciting collaboration with @mark_sansom for MD simulation. nature.com/articles/s4146…
A Nature paper reports a single-step method to convert non-neuronal brain cells into functional neurons, demonstrated in isolated human cells and in mice. The technique is shown to reverse symptoms of Parkinson’s disease in a mouse model of the disease. go.nature.com/2VKke4L
A Special Issue on #TRPA1 Channel is open for submission: mdpi.com/si/53959 #mdpiijms via @IJMS_MDPI
Congrats to Lund on new clues in understanding the calcium modulation of our beloved TRPA1 receptor: Calcium activates purified human TRPA1 with and without its N-terminal... sciencedirect.com/science/articl…
We have been enchanted by the TRPA1 channel for over 10 years. Happy to announce the publication of the perspective article gathering recent intriguing findings. frontiersin.org/article/10.338…
Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells. #ionchannels Cells zpr.io/tuV6y
Volatile anaesthetics inhibit the thermosensitive nociceptor ion channel transient receptor potential melastatin 3 (TRPM3). #ionchannels Biochem Pharmacol zpr.io/tyLPy
Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/31866091
Our new work about temperature sensitivity of #TRPA1 is out now mdpi.com/603450 @MDPIOpenAccess #pain #inflammation #sensory #Physiolrev #openaccess #MDPI #heat #nociception
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