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NEJM @NEJM

The New England Journal of Medicine is the world’s leading medical journal and website. NEJM.org Boston, MA Joined March 2009
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NEJM @NEJM

3 hours ago

An 11-year-old girl presented with a 1-month history of right thigh pain that worsened at night. Radiographs of the knee revealed a metaphyseal osteoblastic lesion with a sunburst appearance. Read the full case details in the Images in Clinical Medicine article “Osteosarcoma”: nej.md/4aanaOj

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NEJM @NEJM

3 hours ago

Drs. Bianca Rocca and Hugo ten Cate review current strategies for anticoagulation reversal in major bleeding events or urgent surgery as well as specific antidotes, limits of available evidence, thrombotic risks, unmet therapeutic needs, and ongoing research. Read the Review Article “Antidotes for Anticoagulation Reversal”: nej.md/4xgOUdI Wondering how you might use this article in practice or teaching? AI Companion can help. Try it with this article.

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Paul Sax @PaulSaxMD

7 hours ago

For those who do hospital-based medicine, the ritual of the daily exam discussed here. We're probably going to keep doing at least some of it even though it usually yields nothing. Here's why. (Link in ⬇️) @NEJM @NEJMClinician

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NEJM @NEJM

3 hours ago

In this study involving 12 patients with X-linked retinoschisis who received subretinal gene therapy, no adverse events of grade 3 or higher were reported, and changes in retinal structure were consistent with a therapeutic effect. Full study results: nej.md/4ofdSGk NEJM subscribers: AI Companion is available with this article — ask targeted questions and quickly surface specific details. 🕵️‍♀️

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NEJM @NEJM

4 hours ago

Paul Bastard, MD, PhD, and Jean-Laurent Casanova, MD, PhD, describe the scientific foundations of a study implicating autoantibodies against interleukin-10 in persons with inflammatory bowel disease. Read the editorial “Autoantibodies against Cytokines — From Infection to Inflammation”: nej.md/4e1EZ4s

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NEJM @NEJM

4 hours ago

Neutralizing interleukin-10 autoantibodies were found in a subgroup of patients with inflammatory bowel disease and in no controls without IBD. Seropositivity was strongly associated with the IBD HLA-DRB1*01:03 risk allele. Full study results: nej.md/4dXZ3od Science behind the Study: Autoantibodies against Cytokines — From Infection to Inflammation nej.md/4e1EZ4s

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NEJM @NEJM

4 hours ago

The authors of a new Perspective write that collaboration between independent scientific organizations and technology companies could represent a path forward for increasing access to high-quality health information. But caution is warranted. Read the Perspective by @VictorDzau, MD, and Laura DeStefano, BA, of @theNAMedicine: nej.md/4ezaYc8

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NEJM @NEJM

5 hours ago

Efforts toward Equity: Advancing Indigenous Health Equity in Medical School Curricula nej.md/4uKMORd #MedEd #PublicHealth

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Roon Doctors @roondoctors

7 hours ago

We’re thrilled to welcome the New England Journal of Medicine (@NEJM) to Roon. At the heart of this effort is a simple idea: Research should be social. For generations, medical journals have shaped how physicians learn, debate, and practice. But the way doctors consume information has changed dramatically. We are all pressed for time. We are all inundated with summaries, alerts, podcasts, guidelines, newsletters, and now AI-generated answers. Those tools are useful. But something important can get lost when medicine is learned by bullet point. The best learning in medicine has always been communal. A paper becomes more meaningful when a cardiologist, an internist, an oncologist, a surgeon, a trainee, and a public health expert can all bring their lens to it. A trial becomes more alive when doctors ask not just “what did it show?” but “how should this change care?” “who does this apply to?” “what are we missing?” and “how are others actually practicing?” That’s what we’re building on Roon. A space where the literature can become a conversation. Where doctors can engage on their own time. Where specialty silos can break down. Where research is not just published, summarized, and forgotten, but discussed, challenged, contextualized, and carried into practice. In the age of AI and infinite information, the scarce resource is not content. It is trusted interpretation, nuance and experience. It is the ability to learn from peers who are taking care of real patients in real systems with real constraints. That's why we’re honored to have NEJM join Roon to help create a new digital home for research discovery. Join NEJM on Roon and let’s all start learning together.

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NEJM @NEJM

7 hours ago

Correspondence: Targeting of Wnt–β-Catenin Pathway in Recurrent Ameloblastoma nej.md/4e5IgON NEJM subscribers can use AI Companion to ask questions about this article and quickly find the details you need. Follow the link above and try it now. #Oncology

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NEJM @NEJM

9 hours ago

Brief Report: Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery nej.md/4cXAAPt #Neurology #Genetics

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NEJM @NEJM

10 hours ago

In a new blog post, @MKIttlesonMD recalls a moment when a heart transplant patient taught her symptoms aren’t always medical. Read “Life Is a Series of Dogs”: voices.nejm.org/doi/full/10.10…

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NEJM @NEJM

11 hours ago

For interviewing residency applicants, would you recommend continuing virtual-only residency interviews or support a return to in-person residency interviews? Vote on the best option: nej.md/4x7Tefc

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NEJM @NEJM

13 hours ago

Presented at the Collaborative Clinical Trials in Anesthesia Meeting: In a cluster-randomized trial involving patients having major noncardiac surgery, tranexamic acid reduced the need for red-cell transfusion during hospitalization and was noninferior to placebo for venous thromboembolism within 90 days. Full TRACTION trial results: nej.md/4e8QKF4 Editorial: TRACTION for Greater Surgical Use of Tranexamic Acid nej.md/4ohASVk

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NEJM @NEJM

15 hours ago

Presented at #CCR26: Among critically ill adults with acute respiratory failure, neither carbocisteine nor hypertonic saline reduced the duration of mechanical ventilation, and each strategy was associated with harm. Full phase 3 MARCH trial results: nej.md/3PUyHdA @CritCareReviews

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NEJM @NEJM

17 hours ago

Presented at #CCR26: Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy. Full LOGICAL trial results: nej.md/4x7TavY @CritCareReviews

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NEJM @NEJM

a day ago

Perspective by Louise Aronson, MD: Perversity in Medicine — When Vocation and Corporatization Clash nej.md/4eiTXD0 #HealthPolicy #MedicalEthics

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NEJM @NEJM

a day ago

Can a transdermal estradiol patch reduce hot flashes in prostate cancer therapy? In our latest video in partnership with @DGlaucomflecken, Gynecology meets Urology to settle their "hormone beef" with a trial assessing the safety and efficacy of transdermal estradiol patches in patients with prostate cancer. Read the full study for free: nej.md/DrG42 #oncology

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NEJM @NEJM

a day ago

Brief Report: Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy nej.md/4forWeq Correspondence: Kidney Transplantation after Clearing Anti-HLA Antibodies with CD19 CAR T Cells nej.md/4e1Gn5E #Nephrology

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NEJM @NEJM

a day ago

In a multicenter trial involving patients with acute hypoxemic respiratory failure, 28-day mortality with high-flow oxygen was not significantly different from that with standard oxygen. Full SOHO trial results and Research Summary: nej.md/3PSld1Z

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