Neurophysiology AR 🇦🇷 @NeurophysioLab

Neurophysiology group studying ghrelin, GHSR, brain control of appetite and more. Research lab from La Plata, #Argentina #IMBICE. #CONICET/#CIC/#UNLP #Perello Joined June 2020

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Neurophysiology AR 🇦🇷 @NeurophysioLab

a year ago

(3/3) Here’s the link to the full article: pubmed.ncbi.nlm.nih.gov/39823403/

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Neurophysiology AR 🇦🇷 @NeurophysioLab

a year ago

(2/3) For years, ghrelin has been the star of the show. But LEAP2, a peptide with unique properties, has emerged as a key player that reshapes our understanding of how GHSR works.

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Neurophysiology AR 🇦🇷 @NeurophysioLab

a year ago

Just published in Endocrinology! A provocative mini-review on LEAP2, the second ligand for the ghrelin receptor (GHSR). Is it time to challenge the ghrelin-centric view of the GHSR system? 👇👇 (1/3) 🧵

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Neurophysiology AR 🇦🇷 @NeurophysioLab

a year ago

🎯 These findings underscore the importance of GPCR crosstalk in the brain. Could this pave the way for dual-targeted therapies? Stay tuned for more breakthroughs! 👀✨

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Neurophysiology AR 🇦🇷 @NeurophysioLab

a year ago

2️⃣ GHSR & CB1R 📄 pubmed.ncbi.nlm.nih.gov/39702649 We uncovered intersections in the hippocampus, amygdala, and cortex. Transcriptomic analyses revealed distinct neuron subsets co-expressing both, hinting at integrated roles in physiology.

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Neurophysiology AR 🇦🇷 @NeurophysioLab

a year ago

🚨 Hot off the press! Our lab's latest research explores how GHSR co-distributes with other key GPCRs in the brain, unlocking exciting insights into energy balance, metabolism, and behavior. 🧠✨

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

@j280480 Happy to hear you enjoyed! Thanks

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

🚨 New Study! 🚨 Contrary to our hypothesis, we found that hypothalamic tanycytes internalize ghrelin from the CSF and transport it to the end feet, potentially reducing ghrelin levels and its central effects. Check out the full details here: sciencedirect.com/science/articl…

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Zane Andrews @zane_andrews1

2 years ago

Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism. We deleted ghrelin receptors in the olfactory bulb and saw many interesting effects - see graphical abstract @ZigmanLab @Jeff_Neuro @Stark_BrainSci sciencedirect.com/science/articl…

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Pan American Neuroendocrine Society @paneuroendo

2 years ago

Join us for our Neena Schwartz Lecture on Reproductive Neuroendocrinology honoring the career of Prof. Ei Terasawa on Sept 27, 12PM ET. Register here: partners.zoom.us/webinar/regist…

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

@drmikkelc @Filip_Knop In any case, the biological basis that link the concentration of LEAP2 in human milk with adiposity and body weight in the first year of life remains to be determined.

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

@drmikkelc @Filip_Knop Hi! At least six mechanisms have been identified that explain the absorption of breast milk peptides into infant circulation, as reviewed here: pubmed.ncbi.nlm.nih.gov/27151491/. Worth considering for LEAP2!

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

@thewilliamslab @ZigmanLab @ObesitySociety @UTSWInternalMed @UTSWdiabetes @UTSW3MD @UTSWBrain @utsw_endocrine @UTSWNeurosci @UTSWScience @ObesityWeek @UTSWIMchief Bravo!! Congrats Jeff! Well deserved!

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

We dug deeper… 🔬 Our study also tracked LEAP2 levels in lactating moms and their 6-month-old infants. Curious about what we found? Spoiler: It’s linked to body weight changes! 💡

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

✨ First evidence ever that LEAP2 is not only in human milk but also correlates with mom and baby’s growth! 🤱👶 Could this be a game changer for early-life development?

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

🚨 New findings alert! 🚨 Ever wondered what's in human milk beyond nutrition? 🍼 We’ve just discovered something fascinating: LEAP2 is there! And it's doing much more than we thought… 👀 👇 sciencedirect.com/science/articl…

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Daniel J Drucker @DanielJDrucker

2 years ago

Here more evidence that central GHSR drives binge-like alcohol drinking independently of peripheral ghrelin nature.com/articles/s4138… @molpsychiatry

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

Thus, the physiological implications of LEAP2 seem to depend on nutritional status. Preprandial LEAP2 concentration was found to be inversely associated with energy intake and, unexpectedly, was found to decrease after a high-protein meal.

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

The study reveals a link between plasma LEAP2 and BMI, waist circumference, motor impulsivity, and reward responsiveness in individuals with obesity, but not in those with normal weight, where plasma LEAP2 is linked to fullness and glycemia.

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Neurophysiology AR 🇦🇷 @NeurophysioLab

2 years ago

NEWS NEWS! New paper out! This time we studied LEAP2 in human plasma and its association with feeding behaviour. Here is what we found 🧵👇 …ubs.pericles-prod.literatumonline.com/doi/10.1111/do…