@Neurosharp @Neurosharp
Neuroscientist, Neurologist, Dad, & Network enthusiast - Director of Care Research & Technology Centre, UK Dementia Research Institute bit.ly/YSYrq2 Prof. Imperial & DRI Joined June 2010-
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@Neurosharp retweeted
New paper out in Alzheimer's & Dementia 🧠 We combined resting-state pupillometry-fMRI, neuromelanin MRI of the locus coeruleus, and cognitive testing in 64 people with Alzheimer's and 26 controls to ask how arousal shapes cortical dynamics in AD. 🧵
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Pupil-linked arousal tracked synchrony in real time. A weakened arousal system may flatten the brain’s dynamical landscape, raising the possibility that arousal-modulating treatments will be effective treatments. @michaelcbdavid Open access: doi.org/10.1002/alz.71…
Why does Alzheimer’s disease cause problems with attention? Attention falters early in AD. Our new paper points to the brain’s arousal system: as the locus coeruleus degenerates, cortical synchrony drops and the brain can’t hold the states attention needs.
Could focusing on the noradrenergic system change how we treat Alzheimer's? Led by Michael David with @PareshMalhotra and the CR&T team. #Alzheimers #Dementia #UKDRI
New in Alzheimer's & Dementia: using neuromelanin MRI in people with Alzheimer's, locus coeruleus (noradrenaline) integrity tracked AD pathology, symptoms & rate of decline — a possible treatment target. doi.org/10.1002/alz.70…
The UK DRI Care Research & Technology Centre team showing our Minder technology at the Great Exhibition Road Festival. Great work everybody showing how we can better care for people living with dementia! The Centre: ukdri.ac.uk/centres/care-r… Festival: greatexhibitionroadfestival.co.uk
@Neurosharp retweeted
Many congratulations to @IngaKoerte and Nikolaus Plesnila for an excellent @ENONeurotrauma meeting. Great fun, great hospitality and great scientific programme.
@Neurosharp retweeted
Can’t believe it’s been a week since our launch of Friend’s of the Care Research & Technology Centre (Friend’s of CR&T), fantastic event bringing together those interested in being at the heart of our research, find out more 👉 imperial.ac.uk/uk-dri-care-re…
@Neurosharp retweeted
Really interesting! Although traumatic brain injury (TBI) is associated with ⬆️ Alzheimer's risk and ⬆️ phospho-tau181, this study shows phospho-tau181 is not elevated in the first year after moderate-to-severe TBI jnnp.bmj.com/content/early/… @nsngraham, @jmschott, @Neurosharp
@Neurosharp retweeted
Fantastic to speak at this years @UKDRI Connectome event about…well….me. Really enjoyed speaking about my path, the wheel of skills and working in the grey (where the magic happens). Finding out about my panel members was an amazing bonus!
@Neurosharp retweeted
Super interesting review from @sj_marzi on the application of AI and machine learning in experimental medicine for dementia research👩💻👩🔬🧠 Read more in @alzdemjournals👉buff.ly/3PzcVb8
@Neurosharp retweeted
No big deal - solanezumab targeted soluble monomers the idea being to pull amyloid out of the brain like a sponge - but it didn’t clear amyloid. I really don’t understand why the company pursued it so long I would have dropped years ago (easy to say now)
Bad news in #Alzheimer research.. #solanezumab, a drug targeting monomeric amyloid-β species, did not slow cognitive decline in patients with preclinical Alzheimer's in a large cohort of patients. nejm.org/doi/full/10.10…
@Neurosharp retweeted
Pleased to see this comment with @Neurosharp published looking at the great work of the TRACK TBI team on dynamic patient trajectories years post-injury. More to be done to understand things at a mechanistic level but key implications for patient monitoring & treatment trials.
New online! Clinical outcomes evolve years after traumatic brain injury dlvr.it/Sw0fB8
@Neurosharp retweeted
Acetylcholine modulates the temporal dynamics of human theta oscillations during memory nature.com/articles/s4146… #neuroscience
Congratulations!
Reader in Brain Biomechanics @ImperialDyson @imperialcollege since today. Credit to the past and present members of my team and collaborators. Thanks team for the lovely cake.
@Neurosharp retweeted
This month's @Brain1878 contains a set of important articles on #Parkinsons and #LewyBody dementia, including reviews on alpha-synuclein and bradykinesia, papers on cholinergic loss, mechanisms underlying rigidity, impulse control disorder and cognition academic.oup.com/brain/issue
@Neurosharp retweeted
So much respect for @englandcricket and @CricketAus for raising awareness of dementia in such a powerful way (and for entertaining us with such wonderful cricket all through this Ashes series)
This was quite the gesture ❤️ The England team wore different shirts to highlight the confusion caused by dementia.
Thanks Adel.
@Brain1878 @Neurosharp Very impressive work @Neurosharp and @GhajariMazdak
@Neurosharp retweeted
By analysing videos of concussions in professional American football games and modelling the impacts, Zimmerman et al. show that loss of consciousness is associated with deformation in brainstem regions containing nuclei involved in arousal. tinyurl.com/2s4kp6x6
@Neurosharp retweeted
Interesting study need more like this please looking at dementia risk factors. Frustratingly ambiguous findings (primary outcome solidly negative) further targeted trial work needed for hearing aids, but some suggestive benefits in high risk subgroups. More biomarkers/ diagnoses?
#AAIC23 While hearing aids did not have an impact on cognitive decline over 3 years in a general population, treating hearing loss protected against cognitive decline in older adults at greater risk of dementia, finds a new trial: hubs.li/Q01XYp_M0
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