ObarLab @ObarLab
Professor @GeiselMed @Dartmouth @DMS_MicroImmuno; Laboratory of Antifungal Immunity // Director @MCBDartmouth // JV Soccer Coach @hcaneswirl geiselmed.dartmouth.edu/obar/ Lebanon, NH Joined March 2020-
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ObarLab retweeted
👉 HIF activity prevents proper macrophage maturation Deleting VHL → stabilizes HIFs → immature AM phenotype Only removing BOTH HIF-1α + HIF-2α fully restores identity 👉 HIF signaling is the dominant driver downstream of VHL
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ObarLab retweeted
#InterferonPower! #InflammasomePower! 💥With @kjena21 &co we show @NatImmunol that our fungal adjuvant #Mannadjuvant, via IL1 & IFNs, prolongs & potentiates protection of #mRNA #vaccines, broadening it to new variants & overcoming antigenic imprinting! 👉 nature.com/articles/s4159…
ObarLab retweeted
#WeekendRead! #InterferonPower! Cook, Green &co show @JCellBiol that macrophage cell #volume controls their inflammatory response & that macrophage #swelling increases IFN induction synergizing with pathogen-associated molecular pathways! doi.org/10.1083/jcb.20…
ObarLab retweeted
🚨 We’re hiring! Assistant Professor in Immunology @ UMN CFI + LMP seek researchers (including but not limited to inflammation, infection, cancer, neuro, systems immunology). 📍 hr.umn.edu/jobs/Find-Job 🧪 Job ID: 373424 Please share! #Immunology #AcademicJobs#FacultyJobs
@AnukulShenoy @motile_microbe @bmoore_beth @robertpdickson @UMMicroImmuno @UM_PCCM Congratulations!
ObarLab retweeted
Trained Immunity friends, we are excited to see you in Montreal in the Fall ! Register w the early bird rate 🫶
ObarLab retweeted
Latest data from the lab out now in mBio. We show that the antibiotic vancomycin directly impairs antifungal function of macrophages via mitochondrial dysfunction. Lots of lovely imaging in this one from @EbRyhmer ! Check it out here: journals.asm.org/doi/10.1128/mb… #antibiotics #fungi
🚨Our newest preprint on the role of iron overload in intiating Influenza-Associated Pulmonary Aspergillosis (IAPA) that was led by recent @MCBDartmouth graduate Dr. Madeleine Grau! biorxiv.org/content/10.648…
ObarLab retweeted
A new study from the Dang Lab at the Ragon Institute, published in the Journal of Experimental Medicine, has found that the body's immune system inadvertently protects a dangerous fungus from being destroyed. Read more: ragoninstitute.org/2026/04/dang-l…
🎉🍾 Congratulations to the newly minted Dr. Madeleine Grau, an @MCBDartmouth PhD student, who successful defended her thesis on the role of iron in the initiation of influenza-associated pulmonary aspergillosis (IAPA).
ObarLab retweeted
🗓Full list of invited speakers for 2027 GRC Immunology of Fungal Infections is now online! 🍄Check out the fantastic line-up and get your application in early - this meeting is typically oversubscribed! Lots of opportunities for talks from the abstracts grc.org/immunology-of-…
ObarLab retweeted
Fungal diseases are notoriously difficult to treat because these often occur in the setting of impaired immunity. Improving outcomes is likely to require developing immunotherapies. The first conference devoted to this topic will occur this summer. aegeanconferences.org/conferences/203
Jennifer Hunt Named Dean of Geisel School of Medicine home.dartmouth.edu/news/2026/04/j…
ObarLab retweeted
How outcomes in relapsed/refractory multiple myeloma changed, from 1986 to 2026
ObarLab retweeted
In the second installment of the short series around fungal infections, Jatin Vyas MD, PhD, discusses the increase in Candida auris including its unique clades and past challenges in diagnosing this difficult-to-treat infection. @jmvyasmdphd contagionlive.com/view/understan…
ObarLab retweeted
Aspergillosis: An Update on Epidemiology, Risk Factors, Diagnosis, Susceptibility, and Treatment doi.org/10.3390/jof120…
ObarLab retweeted
Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Pr... sciencedirect.com/science/articl…
ObarLab retweeted
Role for NF-κB in #herpes #encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity. From from Manja Idorn, Søren R. Paludan and colleagues: hubs.la/Q046VYWH0 📘 In our #InnateImmunity collection: hubs.la/Q046V_rv0 #KSInnateImmune26
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