SMaHT Network @SMaHTnetwork
The SMaHT Network aims to transform our understanding of how somatic mosaicism in human cells influences biology & disease. St. Louis Joined May 2023-
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Registration is now open for the August 2026 Hackathon, a hybrid event focused on collaborative approaches to genomics and bioinformatics research! Learn more about the event and register: fritzsedlazeck.github.io/blog/2026/hack…
What is the biggest gap in somatic variation research today? In this Q&A, Alexej Abyzov, PhD, discusses the importance of studying somatic mutations at the single-cell level and how SMaHT is helping advance this area of research. ▶️ youtu.be/2S2d8lxy4sk
Join the 10th Annual Single Cell Genomics Day on June 12! Explore the latest advances in single-cell and spatial genomics, featuring talks from leading researchers across the field. Free livestream, no registration required: satijalab.org/scgd
Researchers studied nearly 500,000 genomes, revealing that mosaic chromosomal alterations accumulate in predictable patterns with age, offering new insight into clonal expansion and blood cancer risk. Uncover the science behind it: nature.com/articles/s4158…
Analysis of nearly 12,000 normal tissue samples reveals ongoing mutagenic processes across healthy human tissues, offering new insight into baseline somatic mutation patterns and disease-associated mutagenesis. Read more: pubmed.ncbi.nlm.nih.gov/41756945/
The SMaHT Genome Assembly Analysis Focus Group is working to develop high-quality genomic assemblies to improve detection and interpretation of somatic variation. Learn more about SMaHT focus and working groups: smaht.org/working-groups/
Blog spotlight: Researchers identified rare somatic mutations in brain and spinal cord tissue that may contribute to sporadic Amyotrophic lateral sclerosis and Frontotemporal dementia. Read more: mgriblog.org/science-insigh…
A recent preprint explores how donor-specific assemblies improve the detection of somatic structural variants. Using a personalized assembly identified 1.8× more validated variants than standard references, especially in repeat-rich regions. biorxiv.org/content/10.648…
How can studying somatic variation improve human health? Christopher Grochowski, PhD, shares how SMaHT research is uncovering genetic differences across tissues to better understand disease and advance personalized medicine. Watch here: youtu.be/Rve7hZgR0Uk
Deep sequencing reveals rare, low-frequency somatic mutations in ALS/FTD genes may contribute to sporadic neurodegeneration. Uncover the science behind it: biorxiv.org/content/10.110…
New research supported in part by SMaHT finds cancer-associated mutations in brain immune cells may contribute to Alzheimer’s disease, pointing to new directions for diagnostics and treatment. Learn more in the Boston Children's Hospital press release: childrenshospital.org/newsroom/media…
What are the biggest gaps in somatic mosaicism research? What tools or data are missing? Share your ideas with NIH and help guide future investments: 🔗 go.nih.gov/SMaHT-RFI 📅 Submit by May 30, 2026
SMaHT researchers will be presenting upcoming posters at conferences across the U.S. & Europe, highlighting work across ELSI, TPC, and website teams. Stay tuned for where to find us and learn more about these efforts!
The 2026 Human Cell Atlas General Meeting happens June 16 - 18 in Boston, MA. Join the Human Cell Atlas community as it marks 10 years and looks ahead. Virtual option available. Register: events.humancellatlas.org/2026HCAGM/
Uncover how single-cell approaches reveal somatic mutation variation across cell types, exposures, and lineages, further advancing cell–type–aware mutation profiling. Read the preprint: biorxiv.org/content/10.110…
Our SMaHT Associate Members play a key role in advancing the network, contributing to somatic variant catalogs, developing new sequencing tools, and shaping data resources that deepen our understanding of human biology. Learn more: smaht.org/associate-memb…
The NIH Common Fund is seeking community input to shape the future of somatic mosaicism research. Share perspectives on priorities, technologies, and data needs. Responses due by May 30: go.nih.gov/SMaHT-RFI
Why build a comprehensive catalog of somatic variants? In this Q&A, Elizabeth Chun explains how creating a high-quality, searchable reference across tissues can advance our understanding of human health and disease. ▶️: youtu.be/6N1FHMqozHo
Looking for the SMaHT Network across social media? Visit our Linktree to find all SMaHT platforms in one place and stay up to date on the latest research, tools, and consortium updates. linktr.ee/smahtnetwork
New Preprint: TumorLens introduces a unified long-read framework that detects SNVs, indels, SVs, CNVs, LoH, and CpG methylation in a single assay, enabling more comprehensive tumor profiling and insights into mechanisms like immune escape. Read more: medrxiv.org/content/10.648…
CFDE Workbench @CfdeWorkbench
21 Followers 51 Following The Common Fund Data Ecosystem (CFDE) Workbench is a portal developed by the CFDE Data Resource Center (DRC). It is available from: https://t.co/cyyAqMNFa8.
AviMaayan @AviMaayan
2K Followers 741 Following Professor, @IcahnMountSinai; Director, https://t.co/KjdGw5Ny1E #bioinformatics; Principal Investigator, @MaayanLab @CFDEWorkbench
Claudia M Carvalho @CMBCarvalho
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choiLab @jungminchoilab
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Alba Meira @AlbaRMeira
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Franco Izzo @FrancoIzzo85
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Eunju Kim @Julie300652
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Eunjung Alice Lee @EAliceLee2
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Fenia Fotopoulou @FeniaFotop
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Glennis Logsdon @glennis_logsdon
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Youpu Chen @chenhongpu1
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Seungho Oh @seunghooh... @dancewithsun
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Fran Supek @FranSupek
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Yang Zhang @zocean636
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Dylan Duchen @DylDuch
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Jun | Relationship & ... @UmutDisel
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Liz @Lizz22Liz
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Dan Rohrer @danrohrer
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Michael Corley @michaeljcorley
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David Mas-Ponte @davidmasp
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Nathan Mathieu @N_F_Mathieu
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Maya Kasowski @MayaKasowski
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Eric Minwei Liu @EricM_Liu
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Tom Watkins @tbkwatkins
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Dennis J Yuan @dennisjyuan
108 Followers 170 Following Post-doc fellow @landau_lab @WeillCornell @nygenome | Ph.D. @ColumbiaBME | TL1 Precision Medicine Fellow @ColumbiaMed
Mjkim @j_zuice
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Mike McConnell @mikemc43
885 Followers 1K Following Academic Neuroscientist. Pivoting, cures are where the puck is going. Baseball fan rooting for the StL Cardinals.
Michael Durante @MichaelDurante1
262 Followers 748 Following Hematology/Oncology Fellow @SylvesterCancer | @umjmhimres Alum | MD/PhD @UMiamiMedicine | #MMsm #MultipleMyeloma
Adam Falls @AdamFalls172137
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Buu Truong @buutrg
495 Followers 1K Following PhD student in StatGen @HarvardChanSPH @broadinstitute @alkesprice @pradeepnatarajan @LimingLiangHSPH #MD (Re)tweeting references and interests.
Rohini Janivara @Rohini_JS
210 Followers 611 Following Computational Biologist interested in population genetics and tumor evolution | PhD candidate at @GeorgiaTech
Isidro Cortes-Ciriano @isidrolauscher
2K Followers 2K Following Research Group Leader at EMBL-EBI @emblebi & Associate Faculty at @sangerinstitute. @CR_UK Career Establishment Awardee. Cancer genomics.
Common Fund Data Ecos... @CFDEKC
26 Followers 34 Following The Knowledge Center integrates data and knowledge generated by ground-breaking research programs in the NIH Common Fund Data Ecosystem.
Kristin Baldwin @kkbaldwin238
556 Followers 252 Following Professor at Columbia University, Adjunct Professor Scripps Research and UCSD, Neuroscience, Genomes & Editing, Stem Cells & Reprogramming,
Dexin Yang @YDexin
34 Followers 168 Following PhD candidate @MDA_UTHGrad; BM @ZJU_China; cancer (epi)genomics
Pavithra @lilacpinksky
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Ferriol Calvet @f_calvet
183 Followers 276 Following PhD Student in cancer genomics at @bbglab @IRBBarcelona
Kirtan Dave @DaveKirtan
783 Followers 5K Following # BioinformaticsGeek #spiritual #open source #python #data mining # NetworkBiology # Machine Learning
Oswerfou @Oswerfou780013
60 Followers 529 Following
Sasha_Jakubek @Sasha_Jakubek
133 Followers 290 Following Assistant Professor Biomedical Informatics University of Kentucky. Currently looking at large chromosomal mutations in normal and not so normal cells.💕genetics
Martin Blohmer @martinblohmer
66 Followers 124 Following MD/PhD Student @ChariteBerlin | Studying cancer evolution at @Naxerova Lab of @HMSGenetics
Dan Landau @landau_lab
12K Followers 3K Following Somatic evolution, cancer genomics, epigenomics (Weill Cornell/New York Genome Center). Hemato-oncologist (NYP). Discl.: https://t.co/7TBNcbcVCP
Hunter Shain @ShainLab
1K Followers 691 Following Associate Professor, Dermatology, UCSF. part of HTAN. Melanoma, skin cancer, single-cell, DNA/RNA-seq, spatial transcriptomics, cancer, dermatology, pathology
aLLo Westcott @emmottnuelinks
203 Followers 5K Following Some days, the sun arrives before peace does. Life is an odyssey—a labyrinthine congeries of forks in the road. This choice summons a fork in the road.🌱
Zheng Hu @huzheng1
1K Followers 1K Following Principal Investigator @ Shenzhen Institutes of Advanced Technology, CAS, China | Tumor evolution | Computational biology | Single-cell lineage tracing
Marco Buttigieg @marcobuttigieg_
182 Followers 307 Following MD/PhD candidate in the Rauh Lab at Queen’s University | Vanier Scholar | Clonal hematopoiesis, inflammation, aging, and cancer
Yingping Hou @Yingping_HOU
177 Followers 4K Following Postdoc @BWHNeurology. Interested in understanding the genetic variants in the human brain.
Aoxing Liu @Aoxing2
2K Followers 2K Following postdoc with @dalygene at Broad Institute & MGH. Curious about (large) chromosome alterations & (deep) human pedigrees + immunity, cancer & their interplay :)
Yilei Fu @fuyilei96
141 Followers 396 Following Postdoc @sedlazeck lab at HGSC, BCM. Ph.D @RiceCompSci, Treangen Lab
GREGoR Consortium @GREGoR_research
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ASHG @GeneticsSociety
52K Followers 306 Following The American Society of Human Genetics (ASHG) is the world's largest professional membership organization for human genetics & genomics specialists.
Bradley Harris @Bradleyomics
229 Followers 418 Following Senior Postdoc @sangerinstitute | PhD @EdinburghUni | Lover of all things single-cell 'omic and genetic risk. Anderson lab.
Sheng Chih Jin @PETERJIN999
618 Followers 423 Following Assistant Professor @WashUGenetics | genomics | human genetics | bioinformatics | rare disease | pain | STEM advocate | Basketball lover | Cardinals fan
BCM HGSC @BCM_HGSC
1K Followers 458 Following A world leader in genomics, the Baylor College of Medicine Human Genome Sequencing Center advances biology & genetics through improved genome technologies.
Peter J Park @peter_j_park
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Kathleen Helen Burns @KathleenHBurns
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Jennifer Erwin @jerwinlab
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Christopher M. Grocho... @CGrochowski
384 Followers 1K Following Geneticist working on structural variation and mosaicism at @BCMHouston and @BCM_HGSC. Proponent for science, public transit, and technology. 🏳️🌈 🧬 👨🏻🔬
Boxun Zhao 赵博洵 @ZhaoBoxun
116 Followers 97 Following Understanding the importance and functional impact of transposon insertions in human genomes and diseases; translating scientific discoveries into therapeutics.
Alex Cagan @ATJCagan
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Gabor Marth @MarthGabor
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NIH Common Fund @NIH_CommonFund
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Siteman Cancer Center @SitemanCenter
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WashU Medicine @washumedicine
26K Followers 2K Following WashU Medicine – advancing human health through research, education and patient care. Teaching hospitals: @STLChildrens, @BarnesJewish
WashU @WashU
47K Followers 841 Following Where people matter, and serious work is done. Share your experiences with #WashU and look for @ WashU on Instagram and on TikTok.
Glennis Logsdon @glennis_logsdon
2K Followers 332 Following Assistant Professor at @PennGenetics and @PennEpiInst | T2T, HPRC, & HGSVC member | Loves genomics, epigenomics, & synbio | https://t.co/uAAPsUcWOh
Human Pangenome Refer... @HumanPangenome
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Eric Green @NHGRI_Director
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NIH @NIH
1.7M Followers 225 Following Official account of the National Institutes of Health. NIH...Turning Discovery Into Health®. Privacy Policy: https://t.co/wOGwZ3gX1M Engagement ≠ endorsement
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