Jordan Schultz @Schultz_Lab
Assistant Professor of Psychiatry, Neurology, and Pharmacy Practice at the University of Iowa Carver College of Medicine schultz.lab.uiowa.edu Iowa City, IA Joined September 2011-
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A well-studied, widely used class of drugs for heart health may have benefits for Huntington’s disease. A new paper associated beta-blocker use with delayed onset and slower disease progression. Should you ask your doctor for a new prescription? #cure … ift.tt/pqVuPR5
Beta blockers may delay symptom onset and slow #HuntingtonsDisease progression. The new study results “provide hope that there may be novel targets, such as the autonomic nervous system, for modifying the disease course,” says Jordan Schultz, PharmD spr.ly/6016QHYb4
β-blocker therapy in Huntington disease (HD) was associated with a later age at onset and a slower rate of worsening of clinical symptoms. ja.ma/3CRP43v
We thank CHDI, Inc for their support of the Enroll-HD Platform and especially all of the patients, participants, and caregivers who make this work possible! @HarshmanLyndsay @AmyOstrem @PNopoulos @UIowaNeuro @UIowaPsychiatry @UIPharmacy @IowaMed
We investigated beta-blockers based on previous findings showing that patients with HD have autonomic dysfunction. These findings provide early evidence that the autonomic nervous system may be a novel therapeutic target for slowing the progression of HD.
We are excited to share some exciting findings just published in @JAMANeuro! β-Blocker Use and Delayed Onset and Progression of Huntington Disease jamanetwork.com/journals/jaman… 1/n
Unravelling the role of huntingtin: from neurodevelopment to neurodegeneration New scientific commentary by Jordan Schultz, Mohit Neema & Peg Nopoulos tinyurl.com/59emxnff
More data on α1-adrenergic receptor antagonist Terazosin from @MatthewWeberPhD @narayananlab & colleagues - rodents with VTA dopamine depletion had higher interval timing variability, improved by daily terazosin; Plus more epidemiological #Parkinsons data nature.com/articles/s4153…
While a diagnosis of Marfan Syndrome has not yet been confirmed, this is a tragic reminder of how important an early diagnosis can be. For my 2 yo son, @UIchildrens turned a routine eye appointment into a life-saving early diagnosis of MFS, for which I am forever grateful.
Breaking News: Grant Wahl, the celebrated soccer journalist who died suddenly at the World Cup in Qatar, suffered an aortic aneurysm, his wife said, citing an autopsy. nyti.ms/3Fw0N5w
Most importantly, we want to extend a heartfelt 'thank you' to all of the patients and family members who have participated in this study! Your contributions are moving the field forward and none of this is possible without you!!
This study was led by @PNopoulos @JoHD_Iowa @kids_hd and was the result of significant collaboration amongst members of @UIowaPsychiatry and @UIowaNeuro and enormous support from several dedicated people and groups, including @HDSA, @HDYOFeed, @WeHaveAFace, and @Help4HDI.
Check out our most recent paper in @MDJ_Journal where we report some of the first longitudinal neuroimaging data from kids with Juvenile-Onset Huntington's Disease! …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…
Very pleased to have results from my @ICTSIowa KL2 project published! Great to be able to have multidisciplinary collaborators @boeslab and @HarshmanLyndsay from @UIowaPeds and @UIowaNeuro!
Schultz et al. report that autonomic dysfunction in patients with presymptomatic #HuntingtonsDisease is associated with decreased functional connectivity within the Central Autonomic Network. @Schultz_Lab bit.ly/3EYasmy
Our newest paper in @MDJ_Journal shows that children with long CAG repeats (>50) who were far from their predicted motor onset of HD had striatal hypertrophy that preceded degeneration. @ChANGE_HDstudy @JoHD_Iowa @UIowaPsychiatry @UIowaNeuro …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…
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