Science Translational Medicine @ScienceTM
Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine. science.org/journal/stm Washington, DC Joined February 2011-
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This week's issue of #ScienceTranslationalMedicine is out! A whole-genome test catches residual disease earlier in patients with HPV-linked head and neck cancer, research reveals how immunity influences the premalignant origins of colon cancer, and more. scim.ag/4dZi0ab
A landmark study shows that latent #HIV can convert CD4+ T cells to CD8+ T cells and identifies the latter as a previously overlooked component of the viral reservoir—a surprising finding with critical implications for HIV cure efforts. @sysu_1924 scim.ag/4uklbhB
New work links idiopathic #PulmonaryFibrosis in patients to TLR5 deficiency, which disrupts the lung #microbiome, and shows TLR5 agonists can modulate microbial diversity to protect against the onset of fibrosis in mice. @IRPatNIH scim.ag/4vA7fkA
By encapsulating an engineered CRISPR-Cas12 therapeutic in a #PhageTherapy delivery system, a team designs a precision antimicrobial therapy for Shiga toxin-producing #Ecoli that cleaves the Stx gene and combats infection in animals. @dbikard @EligoBio scim.ag/4u3Ecob
A new #CryoEM analysis decrypts the structure and neutralizing capabilities of monoclonal antibodies against #enterovirus D68 elicited by VLP vaccination in macaques, underscoring the clinical promise of these immunizations. @NIAIDNews scim.ag/4oglb0I
A landmark study shows that latent #HIV can convert CD4+ T cells to CD8+ T cells and identifies the latter as a previously overlooked component of the viral reservoir—a surprising finding with critical implications for HIV cure efforts. @sysu_1924 scim.ag/4uklbhB
The new issue of #ScienceTranslationalMedicine has arrived! A landmark study reveals the HIV T cell reservoir is broader and more plastic than previously thought, restoring the lung microbiome may help to treat idiopathic pulmonary fibrosis, and more. scim.ag/4dL37Ih
A rapid manufacturing pipeline for BCMA-targeting #CARTcells drastically shortens “vein-to-vein” times, and produces cells that demonstrate encouraging safety results in a phase one trial of patients with relapsed #MultipleMyeloma. @DanaFarber scim.ag/4nVUU7E
New #GeneEditing systems named PRINCE and Little Prince employ small molecules to control both nuclease and guide RNAs—achieving precise control over the duration of gene editing and reducing off-target edits in mouse models. @Shenzhensuat_sz scim.ag/4nXF2Bp
A new #AI-based risk model for #BreastCancer that harnesses digital mammograms shows promise for primary prevention when applied to identify 10-year risk in cohorts in the U.S. and Sweden, and outperforms clinical models and the Mirai tool. @ki_meb_biostat scim.ag/4f2omqa
By encapsulating an engineered CRISPR-Cas12 therapeutic in a #PhageTherapy delivery system, a team designs a precision antimicrobial therapy for Shiga toxin-producing #Ecoli that cleaves the Stx gene and combats infection in animals. @dbikard @EligoBio scim.ag/4u3Ecob
A rapid manufacturing pipeline for BCMA-targeting #CARTcells drastically shortens “vein-to-vein” times, and produces cells that demonstrate encouraging safety results in a phase one trial of patients with relapsed #MultipleMyeloma. @DanaFarber scim.ag/4nVUU7E
A creative CRISPR-phage therapy targets toxic E. coli infections untreatable with antibiotics in mice, a rapid production platform for CAR T cells shows promise in patients with multiple myeloma, and more this week in #ScienceTranslationalMedicine. scim.ag/4dRg3et
A four-dimensional biosensor can track disruptions in #autophagy flux within beta cells in real time and show these precede the onset of autoimmune #diabetes, offering a useful tool for beta cell and type 1 diabetes research. @LinnemannLab @IUDeptPeds scim.ag/4nGBvHs
A new generation of therapies that targets the brain-immune system axis stands to reshape the treatment of neurodegenerative disorders such as #AlzheimersDisease, scientists argue in a new Viewpoint. @WeizmannScience scim.ag/4dUSLWh
A new #AI-based risk model for #BreastCancer that harnesses digital mammograms shows promise for primary prevention when applied to identify 10-year risk in cohorts in the US and Sweden, and outperforms clinical models and the Mirai tool. @ki_meb_biostat scim.ag/4f2omqa
A multiplexed platform named NeuroSense enables near real-time monitoring of CSF biomarkers in patients in the neurological ICU, potentially supporting timelier diagnosis and intervention. @Mahla_Poudineh @ShriyaSrinivas3 @jbernstock1 @WaterlooENG scim.ag/3Pg8xBK
A fluorescent reporter for #KidneyFibrosis that sniffs out elevated TG2 can detect fibrotic hallmarks and distinguish mild and severe cases in mice and a small cohort via urinalysis. @sysu_1924 scim.ag/4dYoyWj
New research identifies a subset of #BetaCells that produce mitochondrial reactive oxygen species in response to IFN-alpha—and shows this antiviral response is diminished in patients with #Type1Diabetes. @IUSM_Biochem @LinnemannLab @IUDeptPeds scim.ag/4nJpFwc
Don't miss the new issue of #ScienceTranslationalMedicine! A long-term AI risk model for breast cancer shows promise in primary prevention, next-generation imaging molecules could realize noninvasive tests for kidney fibrosis, and more. scim.ag/4eSv6GY
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