Michael Paley, M.D., Ph.D. (moving to @Bluesky) @drmapaley
Ocular Rheumatologist | @WUSTL_Rheum @WUDeptMedicine | T cell biology and scRNAseq/TCRseq | full of dry and nerdy humor paleylab.com St. Louis, MO Joined May 2021-
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Thank you, @KilianMD, for inviting me to speak at St. Louis University's Rheum Grand Rounds this morning! It's always great to see our neighbors to the East and talk shop! @WashUMedRheum #Rheumatology
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I’m moving to @bluesky!
@peter_morawski Thanks. I will need to take a look!
Excited to share new findings from my #Spondylitis research! Join me & Dr. Barhram Razani in the @CureArthritis Research Spotlight Series on 9/18. We’ll discuss the latest treatment breakthroughs & research. Register today: bit.ly/RSS24PsA #PsA #ArthritisResearch
Michael Paley, M.D., Ph.D. (moving to @Bluesky) retweeted
An enteric start to HLA-B27-associated autoimmune disease? insight.jci.org/articles/view/… Work from @drmapaley, @XinboYang777 et al. suggests early antigen exposure in gut leads to pathogenic CD8+ T cell development in axial spondyloarthritis & acute anterior uveitis. @WUSTLmed
@MaxKonigMD In our data so far, about 75% of the TCRs use TRBV9, and other TRBVs (5,7,etc.) make up the rest. We have a uveogenic TRBV5-5 TCR, so I think we can imagine they are arthrithrogenic as well, but will need more data.
(1/7)Excited to see our latest manuscript in press at @JCI_insight (doi.org/10.1172/jci.in…)! This was a great extension of our continuing multi-institutional, multidisciplinary group to better understand pathogenic CD8 T cells in #axialspondyloarthritis & anterior #uveitis.
(7/7) As always, we must thank key funders who supported this campaign to better understand and treat #spondylitis and #uveitis: @RheumResearch, @CureArthritis, @NIH_NIAMS, #HHMI. @wustl_rheum @WUDeptMedicine
(6/7) We think that more in depth TCR profiling will be needed to stratify patients prior to selecting therapies like BCD180.
Michael Paley, M.D., Ph.D. (moving to @Bluesky) retweeted
Pharmacy benefit managers act as middlemen overseeing prescriptions for millions of Americans to reduce drug costs. A New York Times investigation found they charge steep prices for patients, employers and the government. Our reporter explains how. nyti.ms/3RESDih
@RuthJeanNapier @LUveitis @rheum_cat @MohamadBittarMD @tejpalgill If it was, that would pretty much ruin a HLA-B27+ healthy cohort.
Really enjoyed the invitation to be on Spondycast and talk about where we are for #HLA-B27 research for #axSpA and #Uveitis and where we might be going. Really excited about the possibility of new #Diagnostics and #Therapeutics. @spondylitis
🎙Dive into the latest episode of Spondycast, where host Jill Miller & award-winning ocular rheumatologist @drmapaley enlighten us on his groundbreaking research! Check it out here: spondylitis.org/podcasts #inflammation #uveitis #gut #microbiome
Michael Paley, M.D., Ph.D. (moving to @Bluesky) retweeted
🎙Dive into the latest episode of Spondycast, where host Jill Miller & award-winning ocular rheumatologist @drmapaley enlighten us on his groundbreaking research! Check it out here: spondylitis.org/podcasts #inflammation #uveitis #gut #microbiome
Michael Paley, M.D., Ph.D. (moving to @Bluesky) retweeted
"total number of TCRs in a human, supports Mason’s notion that we should #abandon the ‘one-clonotype–one-specificity’ paradigm suggested by clonal selection theory in favour of a ‘one-clonotype–millions-of‑specificities’reality" nature.com/articles/nri32…
Check out our new lab website: paleylab.com #Research
Michael Paley, M.D., Ph.D. (moving to @Bluesky) retweeted
Thank you, @spondylitis, for awarding Dr. Michael Paley with this years ECI Award! We are so proud of the work he does to help those suffering from #SpA related diseases! ❤️ @drmapaley #ACR23
Alfred Kim @alhkim
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JCI insight @JCI_insight
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4K Followers 3K Following International Foundation for Autoimmune & Autoinflammatory Arthritis “We don’t represent the patient voice, we ARE the patient voice.”
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Volunteer for Health @WashUVFH
272 Followers 70 Following Help improve future health care! Participate in clinical research at WashU Medicine. Call Volunteer for Health for details, 314-362-1000.
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719 Followers 272 Following @WashU Rheumatology Division applies a multidisciplinary approach to the understanding and advancement of research, education and medical care related to rheum.
WUSTL Immunology @WUSTLImmuno
2K Followers 451 Following Immunology Program @WUSTL @WUSTLmed and @WUSTLdbbs - A place where we celebrate people, advances and science #HumansofWUSTLImmuno
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2K Followers 747 Following #TCR and #human diseases “We are all smart. Distinguish yourself by being kind.”—Charles Gordon. Studying T cells in brain doesn't make me a neuroimmunologist!
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3K Followers 531 Following I'm a Rheumatologist, Allergist, and Immunologist interested in medical education, addressing health disparities, and advancing medical communication.
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American College of R... @ACRheum
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