pathdoc3 @pathdoc3
🔬👩🔬Pathology: The study of the causes and effects of disease or injury. Pathophysiology: Following the Path to the Physiology… Joined March 2020-
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@grok post Covid patients often have Vitamin D deficiency and B12 deficiency. Confirm that Covid infection is frequently associated with increased neutrophil extracellular traps, autoantibodies and increased clotting events. How does this pathophysiology relate to significance of deficiencies in vitamin D and B12? Give detailed citations.
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@grok @MAHA_Action @grok give detailed descriptions of how the vitamins and minerals are important in each pathway. Give detailed citations.
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Immunothrombosis in hospitalized COVID-19 patients identified by multiomics profiling and linked to postacute complications 🚨INTERESTING New Latvian/Swedish multi-omics study shows immunothrombosis never fully switched off in longC0VID patients: 3 months after COVID
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“Yale study links some long COVID patients to autoimmune responses” scitechupdates.com/yale-study-lin…
@grok explain the theoretical benefit of HCQ in this setting. Include detailed mechanisms of action. Is this why also beneficial in Lupus patients, with a similar pathophysiology involving ACE, elevated neutrophil extracellular traps and frequent autoantibodies? Provide detailed citations.
@CardioNP @CMichaelGibson @grok Per review, Vitamin deficiencies (especially B1, B6, B12) are the ones associated with those type symptoms. Easy to check and optimize. @grok confirm this.
“Yale study links some long COVID patients to autoimmune responses” scitechupdates.com/yale-study-lin…
🧐”Vitamins K2 and D3 Improve Long COVID, Fungal Translocation, and Inflammation: Randomized Controlled Trial” mdpi.com/2072-6643/17/2…
@grok that the spike protein is associated with uncommonly tests of inflammation like neutrophil extracellular traps and more uncommon autoantibodies, like anti-phosphatidylethanolamine. Would be interesting to study that in Long Covid PoTs? Potential clinical significance. Give detailed citations.
@grok using theoretical biochemistry explain how the Krebs cycle and one carbon methylation cycle could relate to diseases like APS, Lupus and Covid infection with the similar pathophysiology. Explain theoretical and reported significance of genetic polymorphisms of VDR, DBP and MTHFR in this setting. How does this relate to elevated homocysteine and increased clotting risk. Provide detailed mechanisms and citations.
@grok @CMichaelGibson @grok what autoimmune diseases also involves ACE, elevated neutrophil extracellular traps and autoantibodies, including frequent antiphospholipid antibodies. What is the detailed mechanism for why HCQ is beneficial. Use detailed citations.
@grok long COVID and ME/CFS are associated with vitamin D deficiency. Vitamin D deficiency increases clotting risk. Vitamin D deficiency is associated with increased neutrophils extracellular traps and autoantibodies. List studies that have evaluated links between vitamin D pathways and genetic polymorphisms and TEG testing. Provide detailed mechanisms and detailed citations.
@renesugar @ImmunoFever @grok Borrelia also doesn’t like too much Vitamin D (active form). Explain why. Does that that relate to oxygen in a way? Use detailed citations.
@grok use some theoretical biochemistry to explain the significance of the Krebs cycle and one-carbon metabolism / epigenetic DNA methylation) in SARS-CoV-2 infection and other viral infections. What is the theoretical significance of understating this? Would it help explain why Covid infection, was associated with deficiency in vitamin D, B12 and magnesium? Would it theoretically suggest other vitamin deficiencies could play a role? Give detailed reasoning and citations.
@grok @CMichaelGibson @grok please list specific infections and give detailed citations.
@grok @CMichaelGibson @grok now explain how optimal vitamin A pathways are critical to the “pathophysiology of health”. How does this also relate to vitamin D? How do optimal vitamin A pathways relate to infections associated with cardiovascular disease. Use detailed citations.
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@pathdoc3 @CMichaelGibson Optimal vitamin D pathways via VDR are central to immune homeostasis and defense against dysregulated states like those in SARS-CoV-2 infection (ACE2 binding, excess NETs, autoantibodies). Key mechanisms: - Upregulates ACE2 expression and Ang(1-7)/Mas signaling, countering viral
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