Edgar Nollet @EdgarN
Postdoc at University of Copenhagen / Amsterdam UMC - Metabolism, mitochondria, hypertrophic cardiomyopathy, diabetes researchgate.net/profile/Edgar_… Amsterdam Joined February 2009-
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Edgar Nollet retweeted
Michelle Michels presenting the current thinking around genotype-positive phenotype-negative HCM #hcmsummit8 @HCMSummit
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Edgar Nollet retweeted
In HCM, mismatch between ATP supply &demand oxidizes mitochondrial NADPH and increases ROS that trigger &sustain ventricular arrhythmias. Targeting mitochondria prevents VT/VF in HCM. Out on BioRx for now. @ISHR_ES @simon_sedej @IacopoOlivotto @dunjaaks @gabrieleschiat1 @DGK_org
Mitochondrial reactive oxygen species cause arrhythmias in hypertrophic cardiomyopathy biorxiv.org/cgi/content/sh… #biorxiv_physio
Edgar Nollet retweeted
❤️ World Heart Day ❤️ Yesterday was World Heart Day. We are proud to support nine researchers working to improve cardiovascular health, five of whom are supported in collaboration with @DCAcademyDK 🌟 Learn more about our nine researcher's projects 👉 buff.ly/4er7qXg
Huge thanks to all collaborators close to home and around the globe! @rhhoutkooper @mvanweeghel @ConnieJ39640621 @MarguliesLab @1jvaneyk @diederik_kuster @JolandavanderV4
Check out the full paper for more interesting details, summarized in this figure ⬇️
🚨Excited to share our latest study on the metabolic landscape in hypertrophic cardiomyopathy, out now in @Circ_Gen ! Link: ahajournals.org/doi/abs/10.116… 🧵⬇️
Edgar Nollet retweeted
Check out recent work from the Ottenheijm group, just published in @ScienceTM, where they demonstrate that TNNI1 variants cause muscle disease with variant-specific pathomechanisms, leading to either a hypo- or a hypercontractile phenotype. #MyoTwitter science.org/doi/10.1126/sc…
Edgar Nollet retweeted
New Paper Alert! 📜📜 Have you ever wondered what is exactly expressed in the cell line you use? In this recent paper from @AmsterdamPhys authors show that widely used mouse cardiac microvascular cells don’t express essential endothelial markers... sciencedirect.com/science/articl…
Edgar Nollet retweeted
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are anti-diabetic drugs that show beneficial cardiovascular outcomes in patients with acquired heart failure, but can they correct cardiomyocyte dysfunction induced by hypertrophic cardiomyopathy (HCM) sarcomere mutations?
January 19th I defended my thesis 'Metabolic perturbations as trigger and driver of disease in hypertrophic cardiomyopathy #HCM'. Really enjoyed being up there! Next chapter: studying disease mechanisms in patients with HCM and diabetes type II, together with @OchDr!
Edgar Nollet retweeted
nature.com/articles/s4146… @syeung10 @jmhb0 @cohenlaboratory
Edgar Nollet retweeted
Reproducibility of stem-cell-derived models is an important aspect of animal-free innovations moving forward. A Dutch steering group, Amsterdam 4R, chaired by @JolandavanderV4, has been formed to address this issue. Read more about this initiative below: euractiv.com/section/health…
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