Knight Genetics @KnightGenetics

Official account of Prof. Julian Knight's lab at @NDMOxford @OxfordMedSci and @HumanGeneticsOx Using functional genomics to understand the human immune system well.ox.ac.uk/research/resea… Oxford, England Joined February 2016

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Knight Genetics @KnightGenetics

4 months ago

Our new study shows a genetic variant fine-tunes MTOR and immune crosstalk, improving survival in pneumonia-associated #sepsis - toward personalised treatments. Congrats to @pingzhangneho and everyone involved! @HumanGeneticsOx @CAMS_COI_Ox @NatureComms nature.com/articles/s4146…

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Ping Zhang @pingzhangneho

4 months ago

Glad to share our study showing how a common genetic variant impacts immune cell-cell communication and patient survival in pneumonia-associated sepsis, providing a framework for stratified therapy. Thanks to our funders and everyone involved. nature.com/articles/s4146…

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Cell Genomics @CellGenomics

3 years ago

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis dlvr.it/Sn0DBD

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Knight Genetics @KnightGenetics

3 years ago

Our research on the chromatin landscape of ankylosing spondylitis (AS) has just been published in @CellGenomics. An important step towards future drug discovery. Congratulations to @DrCarlaCohen, @HumanGeneticsOx, and and everyone involved!

Carla Cohen @DrCarlaCohen

3 years ago

Really excited to present our research on epigenomics of #AnkylosingSpondylitis, a spinal arthritis. Published this week in @CellGenomics: doi.org/10.1016/j.xgen… 1st authors: Andrew Brown, Ola Mielczarek, Gabriele Migliorini and @DrCarlaCohen A 🧵

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Knight Genetics @KnightGenetics

3 years ago

We are excited to share our recent work mapping the host response to sepsis at single-cell resolution. The study, led by @andrewjkwok and published in @NatImmunol, identifies a subset of immature neutrophils which is increased in severe sepsis. Big thanks to everyone involved!

Nature Immunology @NatImmunol

3 years ago

Julian Knight and colleagues find that altered granulopoiesis and increases in immature immunosuppressive neutrophil subsets are associated with poor outcomes in some patients with sepsis. Read it here: rdcu.be/daDeU nature.com/articles/s4159…

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Carla Cohen @DrCarlaCohen

3 years ago

Congratulations to @KnightGenetics @andrewjkwok @eddiecg and team for their work on immune subsets in sepsis

Nature Immunology @NatImmunol

3 years ago

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Carla Cohen @DrCarlaCohen

3 years ago

Our study on AS epigenomics has been covered by @GenomeWeb Watch this space for link to paper and 🧵

GenomeWeb @GenomeWeb

3 years ago

Ankylosing Spondylitis Genomics Study Points to Genes, Pathways for Drug Discovery. Researchers analyzed transcriptomic and epigenomic features in immune cells from cases and controls alongside genetic risk data. ow.ly/Mxen104EMMw

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Knight Genetics @KnightGenetics

4 years ago

A big thank you to the patients, families, clinicians, and research nurses involved in our sepsis studies, without whom this wouldn't have been possible. Congratulations to @eddiecg @ee_davenport @HumanGeneticsOx @sangerinstitute and everyone else involved!

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Knight Genetics @KnightGenetics

4 years ago

For more information, you can refer to our full publication and the associated R package: R package: bit.ly/3zIRqxs Publication: bit.ly/3FKyhij (14/15)

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Knight Genetics @KnightGenetics

4 years ago

We are excited to share our new study, out now in @ScienceTM! We developed a machine learning framework (SepstratifieR) to stratify infection patients by risk of severe illness. SepstratifieR is publicly available and applicable to sepsis, influenza and COVID-19. 🧵👇 (1/15)