alex rubinsteyn @iskander
Genomics + immunology + ML = personalized cancer immunotherapy | https://t.co/nReVwtVHPq | https://t.co/8DWibdfDWa rubinsteyn.com Durham, NC Joined June 2007-
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as an example of how LLMs have fundamentally altered technical essays: all three of these failed trials have *extremely* sparse coverage outside of singular academic papers or SEC filings. if you are not a cancer-specific investor or curious oncologist, it is unlikely you’d ever be able to discover the existence of them. without the models, i certainly never would’ve found them! and yet, their existence should dramatically alter any conclusions you have on neoantigen cancer vaccines; leaving them out would be missing a lot of the story my point is that the amount of color you can inject into writing is now almost unlimited. the full record of human scientific inquiry is at your fingertips, and you now have the capacity to contextualize fields in a matter of days to weeks rather than years. use it!
How to build a cancer vaccine, and whether they will work this time owlposting.com/p/how-to-build… for the past forty years, the medical field has attempted to create a 'cancer vaccine'. by and large, this effort has not been particularly successful. but things seem different this
Best of luck @iskander! ICYMI, listen to our episode on Geron here:
Starting a newco around unlocking immortality and curing all cancer by modulating the Hayflick limit. Raising at $2b, send term sheets to DMs (yes, you should listen to Approved pod)
@mattgdean03 Inspired by your entrepreneurial spirit!
Starting a newco around unlocking immortality and curing all cancer by modulating the Hayflick limit. Raising at $2b, send term sheets to DMs (yes, you should listen to Approved pod)
@nomad421 @ImranSHaque Centering DIVs is like ARC-AGI-7
@DdelAlamo @ImranSHaque “Bronze Age Doubles”, imports friends list from LinkedIn and generates Bronze Age hill-king versions of their profile pictures
This model release is like one of those Jane Street recruiting challenges but the goal is to get Fable to answer any question at all
I asked Fable "how is babby formed" and you'll never guess what happened next
No new models yet but getting consistently better evals in experiments. For now it will still work with previously released weights. Thanks to @nvidia / @AllThingsApx for letting me burn a lot of Brev credits. And if you’re feeling bold, go find some bugs
MHCflurry 2.3.0rc1 is on PyPI! It’s a very big change set that moves as much work as possible out of NumPy / Pandas and into PyTorch. It also adds multi-GPU support for both training and inference. Training time on a 8xA100 machine is about an hour (down from a week)
@SkepticalAlpaca Imaginations running wild over there
Asked Fable a simple question about signal peptides and got: "Fable 5's safety measures flagged this message for cybersecurity or biology topics" Not looking very useful so far
Opus, Fable, Mythos... Where do they go from here?
The Gospel of Wealth Andrew Carnegie carnegie.org/publication/th… 5 West 51st Street - New York City • 1889
@francoisfleuret Train like an RNN, provide optional attention but with a high dropout?
How to build a cancer vaccine, and whether they will work this time owlposting.com/p/how-to-build… for the past forty years, the medical field has attempted to create a 'cancer vaccine'. by and large, this effort has not been particularly successful. but things seem different this time around. there is, if you pay attention, a dizzying amount of optimism in the air regarding these potential miracle drugs. is it true? have we arrived? are cancer vaccines just over the horizon? maybe! in this 8.3k word essay, i walk through the immunological theory behind cancer vaccines, the variants they come in, the (many) confusing aspects behind their few clinical successes, how machine-learning plays a role in their creation, and what lies ahead in their development it's a very complicated subject, and i am deeply grateful to @iskander and @BenjaminGVincen for patiently answering my questions over the subject!
@comolokko377484 On my list to regen all this with expression and gene features recalibrated into a MAP generating score
FATE1 is a worse CTA than I expected, XAGE1 is much more common than I realized, and PRAME really rules the roost -- highly expressed across many patients in many cancer types. Besides HPV, if you had to point a prophylactic cancer vaccine at any target I'd pick PRAME
@Pheno2geno Nice round number, you get a continuous increase/decrease as you slide from 25TPM to 100TPM
I've been hand-waving a lot about how under-appreciated cancer-testis antigens are as an alt target space for personalized immunotherapies. Starting to put numbers on potential impact, eg how many patients have high expression of 1+ CTA. first attempt: ~1/3 of all cancers
@rongejman Varies by protein but definitely seems important, e.g. we see PRAME peptides by MHC MS in lines with > 30 TPM but not lower, but want to transform these to per-protein abundances based on eg mRNA/protein stability, translation efficiency &c
Anshul Kundaje @anshulkundaje
31K Followers 3K Following Federally funded academic research is the innovation engine of the US economy. Reform is welcome. Destruction will have long term consequences.
Ming "Tommy" Tang @tangming2005
46K Followers 3K Following Director of bioinformatics at AstraZeneca. YouTube at chatomics. On my way to helping 1 million people learn bioinformatics. Also talks about leadership.
Michael Love @mikelove
16K Followers 4K Following Associate Professor of Genetics and Biostatistics at UNC
𝕐 @nomad421
9K Followers 902 Following I ♥ science & compiled, statically-typed programming languages! I dislike slop in all forms, including slop thinking. Views are my own, but are obviously right.
Anne Carpenter, PhD @DrAnneCarpenter
23K Followers 2K Following Discovery in images. Enthralled by science. SAB Recursion, Quiver. Building SyzOnc. Opinions my own. https://t.co/Q7nekPJPBf
Aaron Quinlan @aaronquinlan
16K Followers 1K Following All things genome mutation, software for genomic discovery. Chairperson of @UUGenetics Co-director, DELPHI Data Science Init (he/him) https://t.co/6GKjALLFfk
Anirban Maitra @Aiims1742
33K Followers 3K Following Pancreatic cancer researcher, GI pathologist, husband, dad. Striving to improve the lives of patients with cancer. 🇺🇸 🇮🇳
Oxford Nanopore @nanopore
66K Followers 9K Following 🌍Direct DNA/RNA analysis for anyone, anywhere 🧬Short to ultra-long reads in real-time for rapid insights 🔬Products for research use only
Kevin K. Yang 楊凱�... @KevinKaichuang
23K Followers 6K Following Principal Researcher in BioML @MSFTResearch (@MSRNE). He/him/他. 🇹🇼
Simona Cristea @simocristea
9K Followers 451 Following director of applied AI @TempusAI; prev: faculty @DanaFarber, group leader @Harvard & phd @eth
Elizabeth McKenna @ElizSMcKenna
19K Followers 5K Following Executive Editor of Cancer Discovery @CD_AACR, published by @AACR. @BBS_Harvard/@DanaFarber alum. Native New Yorker. Views/likes/RTs are my own. She/her
ACIR @ACIR_org
3K Followers 1K Following Accelerating Cancer Immunotherapy Research. A free weekly digest of the latest findings in the field. We also make cool images :) Listen to @ImmunoTalks.
Bernard A Fox @BernardAFox
7K Followers 5K Following Harder Chair #FoxLab @ChilesResearch /CEO @UbiVac #immunotherapy/@OHSUSOM /exPres&Ambassador @SITCancer /ex @theNCI /exDetroiter/M GO BLUE/❤️Pinot/Tweets my own
Paul G Thomas @PGTimmune
5K Followers 4K Following Immunology and Vaccine Development Program, Division of Vaccine and Infectious Disease, Fred Hutchinson Cancer Center
Jacob Schreiber @jmschreiber91
5K Followers 1K Following Programmable Genomics Lab @UMassGCB, Technical Steering Committee @NumFOCUS. Prev @impvienna @StanfordMed. Studying genomics, ML, and fruit. Opinions my own.
Ash Alizadeh, MD/PhD ... @AshAlizadeh
4K Followers 4K Following @Stanford Professor. Hematologist/Oncologist & Cancer Geneticist. Computers, tumor genomes, ctDNA, immunology, lymphoma, diagnostics.
Jian Ma @jmuiuc
9K Followers 2K Following Ray and Stephanie Lane Professor of Computational Biology at CMU School of Computer Science @CMUCompBio @SCSatCMU @CarnegieMellon
jp flores (he/him) @jpflores_31
2K Followers 2K Following PhD Candidate in Bioinfo & Comp Biology @UNCBBSP | @hhmi_science Gilliam ‘24 | @NSF GRFP ‘22 | ⚾️🐅@Occidental ‘21 | 🎙️Host @wheredoesitstem Views my own
Klebanoff_Lab @KlebanoffLab
3K Followers 2K Following A translational research lab @MSKCancerCenter focused on the immunobiology and therapeutic potential of genetically engineered #Tcells and #TCRs. Est.2016 @NYC.
Alexander Wittenberg @AW_NGS
5K Followers 2K Following AgBio genomics expert. Exploring new horizons & disruptive innovations in DNA, RNA & Protein sequencing, single cell & spatial omics. 🌱 🥬 🍉 🍏 🫑 🌶 🌽🫐🍌🍓
ThePoorGraduate @firexgamerx
483 Followers 3K Following PhD in cancer research. Still studying cancer. Half the time, I tweet on my investment interests (synbio and biotech).
Jake Boggs @JakeABoggs
230 Followers 221 Following Member of Technical Staff @tzafon_company - what I cannot create, I do not understand
doogoadlksj @NYCorBust
103 Followers 5K Following
J.Aji @J__aji
335 Followers 5K Following
Hamilton Fish @hamiltonfish
102 Followers 1K Following God's in his heaven, all's right with the world
Brandon Steelman @brandonsteelman
60 Followers 210 Following Physician 🩺 scientist 🧬 using CompBio + MolBio to make better tests, from cancer to Covid
Samuel Alber @EggsAndSam7
126 Followers 223 Following CS PhD Student @Stanford | ML + Bio | NSF GRFP
Alexo @alexoterov
641 Followers 7K Following “If it be now, ’tis not to come. If it be not to come, it will be now. If it be not now, yet it will come—the readiness is all.”
Mike @MichaelTanner_
683 Followers 325 Following MD/PhD | placental spatial biology | preeclampsia | westmead hospital/sydney university
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Crowd Funded Cures @CrowdFundedCure
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Joseph Fridman @joseph_fridman
3K Followers 7K Following mr. @fmheclimate | comms @Convergent_FROs | opinions mine | @cunylaw ‘26 | @the_line_edit | editor @IFP | @bbsjournal | @RU_SMLR exec fellow
totoro @Robin_Fighter1
25 Followers 1K Following
Parham Habibzadeh @HabibzadehMD
3K Followers 2K Following Internal Medicine Resident @UPMC @PittGIM| House Moon 🐦🔥| Tweets are mine for education only/not medical advice or endorsements.
Pawel J. Muranski MD @Dr_Muranski
431 Followers 525 Following Physician-Scientist at Columbia University; cancer immunology and immunotherapy
David Duvenaud @DavidDuvenaud
35K Followers 4K Following Machine learning prof @UofT. Former team lead at Anthropic. Working on generative models, inference, & latent structure.
Niklas Anzinger 📍 ... @NiklasAnzinger
6K Followers 5K Following Founder & CEO of @InfinitaCity | Building bio/acc hubs in SEZs and US states | Based in @ProsperaGlobal | Stranded Technologies Podcast
Daniel @datorgra
45 Followers 338 Following
Rohith @RohithMohan
55 Followers 298 Following comp chem, drug discovery, protein modeling and ml. views my own, etc.
Claudio M. Soares @cmslnsoares
309 Followers 508 Following Full Professor @ ITQB NOVA PI of the Protein Modelling Lab @ ITQB NOVA
Warren-Charlie @longtermisms
158 Followers 6K Following Price is what you pay- value is what you get. I have nothing more to add....
Jack Cafferkey @Jack_Cafferkey
73 Followers 316 Following junior doctor: anaesthetics, critical care, trials, meta-research
mads @ForestTrading22
44 Followers 2K Following
🥚 @schmarles_
64 Followers 2K Following
Darren Liu @DL1543
20 Followers 2K Following
Anindyadeep @anindyadeeps
3K Followers 1K Following Building Rosalind, Co-Founder @try_litefold, an AI Co-Scientist for therapeutics
Anar Rzayev @AnarSnowball
393 Followers 2K Following Cooking proteins with ML @ ISTA 🇦🇹 Ex-Research student @ KAIST 🇰🇷 | Prev CS & MATH @ EPFL 🇨🇭 | Bronze medals @ IMO 2017, 2019 🇧🇷 🇬🇧
Rafael Rolli @RafaDeSci
407 Followers 2K Following -Decentralizing scientific moonshots. -Science at @molecule_sci @BioProtocol @peptai_ -Bioengineering and Synthetic biology @epfl
Sal H. @sal_tdot
525 Followers 2K Following Oncologist Drug development Optimist. I believe companies that develop drugs provide the most value to society. https://t.co/9ErzFUGFjf
Bobby Hollingsworth @BobbyHollings
669 Followers 787 Following Co-CEO Deliverome | Postdoc @jwadeharperlab '24 | Ph.D. @BBS_Harvard @WuLabHarvard '21 | @VTEngineering '17 | @bobbyhollingsworth.bsky.social | views = own
Diego Rey @diegoarey
1K Followers 1K Following CEO @GeminiThera. Previously: founder/CSO @GeneWEAVE (acquired @Roche) and @EndpointHealth, visiting partner @YCombinator. ¬σαφές δόκος ἔλεγχος διόρθωσις
Gal Pomerants (Kesten... @KestenGal
53 Followers 118 Following Masters student at Technion, Interpretability research
Flat Chen @flat_chen
190 Followers 138 Following Founder & CEO of @Zettalab_AI｜PhD in Biomedical AI 🧬, Tongji Univ. ｜Ex-SAP GM (Greater China RPA） Leading the development of AI-driven R&D Cloud platform
Harvey @Harvey1593702
0 Followers 304 Following
Shakti @Shakti213086
9 Followers 487 Following
Lior Pachter @lpachter
67K Followers 2K Following Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatter
Anshul Kundaje @anshulkundaje
31K Followers 3K Following Federally funded academic research is the innovation engine of the US economy. Reform is welcome. Destruction will have long term consequences.
Ming "Tommy" Tang @tangming2005
46K Followers 3K Following Director of bioinformatics at AstraZeneca. YouTube at chatomics. On my way to helping 1 million people learn bioinformatics. Also talks about leadership.
Michael Love @mikelove
16K Followers 4K Following Associate Professor of Genetics and Biostatistics at UNC
𝕐 @nomad421
9K Followers 902 Following I ♥ science & compiled, statically-typed programming languages! I dislike slop in all forms, including slop thinking. Views are my own, but are obviously right.
David R. Liu @davidrliu
79K Followers 68 Following Professor at Harvard and the Broad Institute. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1
Anne Carpenter, PhD @DrAnneCarpenter
23K Followers 2K Following Discovery in images. Enthralled by science. SAB Recursion, Quiver. Building SyzOnc. Opinions my own. https://t.co/Q7nekPJPBf
Fabian Theis @fabian_theis
38K Followers 429 Following Computational biologist @HelmholtzMunich, prof @TU_Muenchen & associate PI @sangerinstitute. Dad of 4 and mountain lover. Department news, see @CompHealthMuc
Michael Baym @baym
23K Followers 2K Following Microbiology, evolution, antibiotic resistance, applied math, molecular biotech. Associate Professor @HarvardMed. Basic research is the engine of progress. 🦠🧬
Arjun Raj @arjunrajlab
47K Followers 2K Following Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. https://t.co/fZAnUCqd12
Aaron Quinlan @aaronquinlan
16K Followers 1K Following All things genome mutation, software for genomic discovery. Chairperson of @UUGenetics Co-director, DELPHI Data Science Init (he/him) https://t.co/6GKjALLFfk
Anirban Maitra @Aiims1742
33K Followers 3K Following Pancreatic cancer researcher, GI pathologist, husband, dad. Striving to improve the lives of patients with cancer. 🇺🇸 🇮🇳
antisense. @razoralign
17K Followers 71 Following Between language and causality, ephemeral echoes trace the edge of consciousness— intelligence is a transient footprints. https://t.co/5L9IhaBcRx
Bloom Lab @jbloom_lab
45K Followers 1K Following Lab studying evolution of proteins and viruses. Affiliated with @fredhutch @HHMINEWS @uwgenome. Opinions are my own and do not reflect those of my employer.
Michael Hoffman @mich... @michaelhoffman
23K Followers 6K Following Chair, Comp Bio & Medicine Program, Princess Margaret Cancer Centre, @UHN. Assoc Prof, Medical Biophysics, University of Toronto. COI https://t.co/CvupKNIjZr
Oxford Nanopore @nanopore
66K Followers 9K Following 🌍Direct DNA/RNA analysis for anyone, anywhere 🧬Short to ultra-long reads in real-time for rapid insights 🔬Products for research use only
Kevin K. Yang 楊凱�... @KevinKaichuang
23K Followers 6K Following Principal Researcher in BioML @MSFTResearch (@MSRNE). He/him/他. 🇹🇼
Richard Sever @cshperspectives
20K Followers 1K Following Chief Science and Strategy Officer, openRxiv. bioRxiv & medRxiv Co-Founder
Jason Sheltzer @JSheltzer
19K Followers 2K Following Assistant prof at @StanfordMed. Interested in aneuploidy, mitotic kinases, cancer therapeutics, and drug development. Co-founder x2.
jianlin.su @Jianlin_S
8K Followers 21 Following Grad&Clip&EM is all you need @Kimi_Moonshot Blog: https://t.co/YVxsWylklA , Cool Papers: https://t.co/scS1n1oyaO Interesting link: https://t.co/7Tl4HaVajh, https://t.co/Y5qaxAA9Iy
Xiaoxiao Ma @Pheno2geno
80 Followers 173 Following USTC-COH-MSKCC-CCF-UAB Assisnatnt professor of Genetics. Tweet my own opinion.
Robert Verkuil @robert_verkuil
48 Followers 29 Following
Bryan Wu @bryanzwu_
2 Followers 2 Following
Thomas Hayes @THayes427
739 Followers 152 Following Researcher @biohub. Previously founder @evoscaleai, FAIR @MetaAI. @uchicago alum.
JCmacc @JCmacc1
663 Followers 81 Following Science, skepticism, rugby and cricket. Oh, and stuff. https://t.co/TNxu3WmJXn
Ed Harris @Ed_Harris_
303 Followers 910 Following AI x Bio | CEO at Ligo Biosciences | Prev. Medicine @UniofOxford
Mark Lewis, MD, FASCO @marklewismd
96K Followers 35K Following Director, GI Oncology, @Intermountain. Interests: neuroendocrine tumors, cancer syndromes, empathy (even had a Whipple myself). Tweets my own.
Deputy Commissioner K... @FDA_KyleD
1K Followers 42 Following United States Deputy Commissioner for Food at @US_FDA and Senior Counselor at @HHSgov - Official Account
kevin simler @kevinsimler
26K Followers 648 Following on twitter i value insight and kindness ••• once upon a time i wrote a book: https://t.co/v8jaqX5ml0
Matthias Mann Lab @labs_mann
14K Followers 81 Following The Mann Lab is a pioneer in mass spectrometry-based proteomics. Tweets represent personal views from lab members and Matthias Mann @MPI_Biochem and @UCPH_CPR.
Adam Mainz @MainzOnX
3K Followers 149 Following PyTorch TPU @google | ex @meta | Obsessed with AI & ML Performance | Building what’s next 🔥 | Views are my own
Tiberiu Mușat @Tiberiu_Musat_
771 Followers 951 Following Trying to figure out how AI works 🔍🧠 Currently at @ETH Zurich, previously @EPFL 🇨🇭 LLMs, interpretability, emergence, grokking 🤖
Neriya Fisch @neriya_fisch
10K Followers 309 Following כותב על היסטוריה, אצולה אירופית וסתם סיפורים מגניבים. מגיב על כדורסל. אני פה בשביל האסקפיזם *כל שרשורי העבר נמצאים בHighlights tab
Dan Turner-Evans @DanTurnerEvans
693 Followers 186 Following Applied Physicist, Neuroscientist, Policymaker | Senior Metascience Fellow @ IFP
Bobby Hollingsworth @BobbyHollings
669 Followers 787 Following Co-CEO Deliverome | Postdoc @jwadeharperlab '24 | Ph.D. @BBS_Harvard @WuLabHarvard '21 | @VTEngineering '17 | @bobbyhollingsworth.bsky.social | views = own
The OpenAI Foundation @FoundationOAI
7K Followers 0 Following OpenAI was founded in 2015 as a nonprofit; its mission is to ensure artificial general intelligence benefits all of humanity.
Diego Rey @diegoarey
1K Followers 1K Following CEO @GeminiThera. Previously: founder/CSO @GeneWEAVE (acquired @Roche) and @EndpointHealth, visiting partner @YCombinator. ¬σαφές δόκος ἔλεγχος διόρθωσις
🧬Jacob L Steenwyk @jlsteenwyk
5K Followers 2K Following UC-Berkeley Postdoc🐻, Scientific Consultant Anthropic🏔️, Evomics Workshop Codirector🧬 prev FutureHouseu/Edison, Latch, Mantle (acquired), Vanderbilt PhD
Gal Pomerants (Kesten... @KestenGal
53 Followers 118 Following Masters student at Technion, Interpretability research
Dario prescenzi @___Dario_____
5K Followers 790 Following Those on the margins often come to control the center @atomicfactories
Avi Marcus @Avi_Marcus
165 Followers 288 Following
MoundLore @MoundLore
79K Followers 580 Following I write things. America’s often forgotten past. Fact-driven. Lore-obsessed. Mounds, myths, maps. I understand people.
Tim Yu @timyu
2K Followers 325 Following Neuroscience, Genetics, Genomic Medicine. Tweets my own unless one of our girls has broken into my account again in which case sorry for all the Pokémon pics
Jacob Shell @JacobAShell
16K Followers 1K Following Geographer. Prof at Temple University. Author of 2 books. Elephants. Maps. Archaeofuturist Transportation.
Kiana Ehsani @ehsanik
8K Followers 617 Following Making models smarter @ Anthropic, formerly CEO and Co-Founder @ Vercept (acquired by Anthropic), Climber on the weekends. Opinions are my own.
Cory Kornowicz @cory_jay44
695 Followers 559 Following RIT ‘22 B.S. Bioinformatics and Comp Biology. Developing next-generation drug discovery tools, co-founder/cso @try_litefold @theresidency @inventorsRes
Silvi Rouskin @silvirouskin
14K Followers 1K Following Asst. Prof. at Harvard Medical School. #RNA biology#viruses #AI # https://t.co/Ihy7mZhjL5 @harvardmicro ; opinions are my own. https://t.co/9lMkSHvpn9
levent @__alpoge__
4K Followers 101 Following idiot. cuda og, harvard val, morgan prize, society of fellows, 1 hilbert problem so far, creating friendly, SAFE, delightful, supergenius ..things @anthropicai
Mehtaab Sawhney @mehtaab_sawhney
3K Followers 6 Following
Lijie Chen @wjmzbmr1
7K Followers 437 Following Assistant professor at UC Berkeley EECS Previously: Miller Postdoctoral Fellow at UC Berkeley, Ph.D. in MIT EECS
Hongxun Wu @HongxunWu
2K Followers 396 Following Researcher @OpenAI. Was a grad student at Berkeley theory group.
thebes @voooooogel
21K Followers 1K Following ꙮ there go the ships, and there is that leviathan ꙮ blog/art/fiction/games: https://t.co/aykxqKiXfu, llms @acsresearchorg ꙮ 💞💍📝 @holotopian, she/they 🏳️⚧️
dough though @domenjemec
23 Followers 253 Following Bio, ML, building fun things. | Founder @gptomics Opinions expressed are my own.
Sriram (Rami) Hathwar @hathwar607
366 Followers 723 Following Investor @_DimensionCap. Interested in ML infra and biotech!
BreakingTaps @BreakingTaps
10K Followers 505 Following Material Science, Microfabrication, Microscopy He/him. @[email protected] (Fedi) / @breakingtaps.com (Blue)
Rob Shaffer @ShafferBiotech
1K Followers 598 Following Biotech entrepreneur and consultant. Biochem PhD. Opinions strictly my own.
rcsb pdb 💉🧬💻... @buildmodels
15K Followers 444 Following RCSB PDB promotes a structural view of biology. Funded by @NSF, @thenci, @NIAIDNews, @NIGMS, @NIH, & @doescience. Contact [email protected] with service questions.
Tianyang Mao @tianyangmao
1K Followers 748 Following Jane Coffin Childs Postdoc Fellow in the Hacohen lab @broadinstitute; PhD in Immunology @YaleIBIO; Developing tools to decode and reprogram cytokine biology.Trends for United States
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