Trefely Lab @trefely
Studying metabolic compartmentalization and metabolite signaling to the nucleus @BabrahamInst Cambridge, England Joined March 2015-
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We have an exciting postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬 The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️ For more detail and to apply: babrahaminstitute.livevacancies.co.uk/#/job/details/…
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Calling metabolism enthusiasts looking for a PhD opportunity! We have an exciting project in partnership with DefiniGEN Applications close Nov 24th findaphd.com/phds/project/i…
@JuliannaSupplee @WellenLab @MarmorsteinLab Congratulations @JuliannaSupplee 🎉 Beautiful work
Trefely Lab retweeted
📣Only 1 week left to submit an abstract for the UK's leading #immunometabolism event! #UKimmunomet24 will be packed with cutting-edge #research, plenty of networking & 'Bright Sparks' sessions for #ECRs 🌟 Submit your abstract by Friday 15 March 👉bit.ly/3TUBIKl
@doc_jlmeier @therealdiehllab @uofupharmacy 🙌
@irene_zorzan @AmyWilkinson25 @RuggGunnLab Congrats! 👏
@WellenLab @BMBGGUPENN Congratulations Joyce! 🌟
@MathiasWenes @MiglioriniDenis @ArberCaroline @AlisonJaccard @PCHo_Lab @UNIGEnews @OncoUNILCHUV Congrats 👏
@AZadoorian22 @NatureRevEndo @rob8yang @ximingDu @UNSWBABS @UNSWScience @UNSW A great resource, congrats @AZadoorian22 @ximingDu and @rob8yang 👏
Trefely Lab retweeted
Good morning all! A very Ac-CoA-rich summary of papers in #cancermetabolism and #mitochondrialbiology is out now, don't miss it: biomed.news/bims-camemi/20… @Bims_BiomedNews “The truth is not always beautiful, nor beautiful words the truth.” ― Lao Tzu
@Gerta_Hoxhaj @AranyLab @mzspectrum @WellenLab Thank you 😊
Can histone deacetylation fuel acetyl-CoA metabolism? We teamed up with Ioana Soaita @AranyLab @mzspectrum @WellenLab to answer this question. jbc.org/article/S0021-…
@PatVargaWeisz @AranyLab @mzspectrum @WellenLab Thank you!
So the contribution of deacetylation to whole cell acetyl-CoA metabolism appears limited 🥲Although the contribution may vary across subcellular compartments. Variation in the extent of deacetylation between different histone lysine sites suggests selectivity in this response:
We didn't detect any release into extracellular acetate, so we checked 13C-labeling. We found that up to ~10% of the acetyl-CoA pool was derived from deacetylation, and this label was transmitted downstream into (iso)butyryl-CoA!
Our data are consistent with a model where acetate is preferentially mobilized to maintain other acetylation events (such as shown recently by Mendoza et al @berger_lab @GarciaLabMS) pubmed.ncbi.nlm.nih.gov/35061542/
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