Sean Ward @DNAEngineer
CEO & Co-founder @iGent_AI. Previously Founder @synthace, Relatable, Scale DX igent.ai London Joined March 2011-
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@logangraham @hannu The barrier hasn’t been technology: it has been regulatory stance and belief
@ctjlewis It is more complicated than that however: most providers brainfried their models with RL to go prompt -> outcome. Anthropic models can maintain competing hypothesis and tension for far longer, which allows thesis, investigation, correction, and autonomy.
@ctjlewis In its simplest terms: Anthropic models can reason. Hello from the days of Spellcraft btw.
@jonas @dbreunig @karpathy @grok We did Redis last July: igent.ai/insights/produ…. The truth is, specification is the bottleneck (and a well known system shortcuts that).
Introducing Claude Opus 4.5: the best model in the world for coding, agents, and computer use. Opus 4.5 is a step forward in what AI systems can do, and a preview of larger changes to how work gets done.
@sqs You are assuming those are at odds with each other
@unit_accord @Yuchenj_UW x.com/dnaengineer/st…
@Yuchenj_UW Verifiable engineering tasks, mostly at the scale of entire features, primarily in compiled languages like go or rust, where it can validate the outputs and hill climb. One such public example: igent.ai/insights/produ… with repo of results and all commit/session history.
@_xjdr It natively wants you to be absolutely right (it is Sonnet after all). However, unlike 4.0, it will listen to style and tone instructions on a long horizon basis.
@Yuchenj_UW Verifiable engineering tasks, mostly at the scale of entire features, primarily in compiled languages like go or rust, where it can validate the outputs and hill climb. One such public example: igent.ai/insights/produ… with repo of results and all commit/session history.
The world is rapidly bifurcating between those who have experienced the superhuman capabilities of even current generation models, used properly, and those stuck in the capabilities of the past.
We're excited to share that our agent, Maestro, drafted solutions to all 12 problems from ICPC 2025 World Finals in ~2 hours - using current models, no human involvement, no internet access. We deeply respect the human teams' extraordinary dedication. Note: no official validation
@SimonInmania @matthewclifford Yes, task length is in Replit’s case measured in agent runtime, which can slightly proxy for the metric that really matters: how many man months (or years) of work the agent performs. igent.ai/insights/produ… is several man years in the course of ~70 hours or agent time however.
@simonw Strong recommendation: it takes a very different promoting strategy to maintain attendance across that context: basic system prompt + context + request alone won’t cut it.
@platonovadim @_xjdr Yes, tests are central including leveraging the existing redis client libraries and benchmarks. The entire commit history also shows every round of the AI workflow during building.
It has become clear there is a massive performance and productivity delta growing between engineers who understand and embrace AI, with appropriate tooling and critical analysis, and those who have have remained in the co-pilot era. Never before has it been so possible for those who know what they are doing, to build so much.
Tired of toy AI demos that fizzle in production? iGentAI built Ferrous: A Rust Redis-compatible server outperforming Valkey. 35KLOC, 100% test passing, beats benchmarks. Zero human code. Built in 70 hours of part-time direction. Toys vs. tools—here's the proof.
Our VibeCodeBench evaluations affirm what @Anthropic just announced: Claude Sonnet 4 excels at autonomous multi-feature development. We've seen codebase navigation errors drop from 20% to near zero and strategic refactoring that saves ~500k tokens on multi stage, complex tasks. Proud to power Maestro with this breakthrough.
Introducing the next generation: Claude Opus 4 and Claude Sonnet 4. Claude Opus 4 is our most powerful model yet, and the world’s best coding model. Claude Sonnet 4 is a significant upgrade from its predecessor, delivering superior coding and reasoning.
It's always great hosting @AITinkerers London meetups right after a new model drops... Huge thanks to @rebecca_harbeck from @AnthropicAI, as well as the @iGent_AI team @MSzummer and @samshapley for giving impromptu talks with tons of learnings from early access Claude Sonnet 3.7. We also got to see @HarryCoppock from the @AISecurityInst live demoing 3.7 hacking into a docker container 🫢 And as always, we had some fantastic product, behind-the-scenes and benchmark beating agent talks from Emma Burrows, @moeadham and Sergei Petrov. Huge thanks to team @localglobevc and @ferdisigona for making it happen!
At @iGent_AI, we’ve found @AnthropicAI new Sonnet 3.7 to be quite the powerhouse. Everything from debugging multi language distributed systems, to comprehending and updating legacy codebases, to rapid prototypes or POCS of new technologies. Agentic SWE is now here.
"Agency > Intelligence" @karpathy nailed it, and after 18 months building Maestro, we agree. The real AI leap isn’t just smarts—it’s agency: the ability to act independently, turning assistants into partners.
Hottest week for London AI so far 🔥 Dev Day yesterday and AI Tinkerers tonight! london.aitinkerers.org/p/ai-tinkerers… @monzo @tortus_AI @_lucas_godfrey @QuotientAI @samshapley @lukeharries @stephenbtl
Tom Ellis @ProfTomEllis
26K Followers 593 Following Synthetic Biology & Synthetic Genomics @ Imperial College London and the Sanger Institute. Bilingual in English and DNA. D-/L-
Jason Kelly @jrkelly
33K Followers 3K Following Co-founder and CEO at Ginkgo Bioworks ($DNA)🧬 Former Chair of US National Security Commission on Emerging Biotechnology 🇺🇸
Sebastian S. Cocioba�... @ATinyGreenCell
32K Followers 10K Following Flower Designer at Neoplants ♧ Researcher at Binomica Labs ♧ Degreeless Heathen ♧ Petunia and Snapdragon Breeder ♧ Open Lab Notebook: https://t.co/umYTLluuuw
John Cumbers @johncumbers
19K Followers 2K Following The room where bio partnerships get made. F500 BD, VCs, and 2,000 founders — all in San Jose, May 4–7. https://t.co/wdTABwo6of
Olivier Borkowski @O_Borkowski
7K Followers 2K Following Tenured Scientist in Synthetic Biology (INRAE, Paris Area) Cell-Free ⦁ Bioengineering ⦁ Microbiology 》》》》》Also on bluesky 》》》》》https://t.co/4zpI5kUf4A
Renee Wegrzyn @rwegrzyn
4K Followers 1K Following Inaugural Director, Advanced Research Projects Agency for Health
Michael C. Jewett @MichaelCJewett
9K Followers 463 Following Professor of Bioengineering, Stanford University
whimsy lohan (in SF) @SexyLikeMeiosis
11K Followers 995 Following helping scientists build cool shit @convergent_FROs, writing at Contents May Shift // "an interesting mix of spiritual and hustler" according to my landlord
Sri Kosuri @srikosuri
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Christopher Voigt @Geneticdesigner
11K Followers 825 Following Composing DNA / Professor and Department Head @ MIT Biological Engineering
Twist Bioscience @TwistBioscience
26K Followers 802 Following Synthetic DNA for Health & Sustainability #WeMakeDNA #TwistBlog #WritingTheFuture #TwistBiopharma #ScienceDoesntStop #DiversityIsInOurDNA
Thomas Gorochowski @chofski
4K Followers 2K Following Synthetic biologist, programmer of cells, and lover of all things visual. Wakes up in the morning to learn some of natures secrets and do a spot of fly fishing.
Ross Cloney @rosscloney
3K Followers 475 Following Chief Editor for Biotechnology @NatureComms Synthetic Biology & Solarpunk Tweets are my own thoughts. he/him 🏳️🌈
Emily Leproust @EmilyLeproust
14K Followers 289 Following Entrepreneur & CEO @TwistBioscience. Fascinated by #synbio and #genetics
Eben Bayer @ebenbayer
6K Followers 5K Following Founder/CEO @ecovative + @myforestfoods. Dreaming https://t.co/3lZzn1lOlZ. Working on spaceship Earth. Farm raised in VT. Dad to 4. https://t.co/elGcrq5GpK
David Sun Kong, Ph.D. @davidsunkong
3K Followers 1K Following Director of Community Biotech Initiative @MIT @medialab, microfluidics @metafluidics, organizer @bridgeprogram_, @globalbiosummit, DJ @biotabeats, photographer.
SynBioBeta @SynBioBeta
53K Followers 4K Following The room where bio partnerships get made. Pharma BD, corporate venture, and 2,000 founders — all in San Jose, May 4–7. https://t.co/mdobxJzlQf
Angel Goñi-Moreno @a... @AngelGMoreno
3K Followers 654 Following Computing with living systems | Synthetic biology. Head of the Biocomputation Lab at the @CNB_CSIC.
Tom Knight -- e/🦀�... @TomKnightSynBio
3K Followers 4K Following Engineer of stuff that is alive or computes. Follow us all to that blue place.
Jacek Golebiowski @j_golebiowski
825 Followers 1K Following Co-founder at @distil_labs fine tuning small language models from a prompt. Formerly ML lead @amazon and PhD student at @imperialcollege
José Arcadio Rodríg... @josarc
1K Followers 5K Following Associate Professor @uprrp_biology @UPRRP Former Postdoc @UWBiochem with @AnsariLab Follow our lab @theJARMlab
Sammy @ToughSammy
391 Followers 1K Following Engineering the future of autonomous pharma factories. Dum Spiro Spero
A Zenith Guan @AZenithGuan
3 Followers 125 Following
Anzah Mustafa @AnzahMustafa
12 Followers 209 Following $165.5M Raised | Making Post-Seed founders fundable for first Series-A raise | Deal-flow partners for VCs
Mario Savini @savini_mario
109 Followers 315 Following Ph.D., Adjunct Professor of History of contemporary art, University of Camerino - Italy #MediaArt #BioArt #TransgenicArt #ContemporaryArt
Rowan North @RowanNorth
31 Followers 358 Following
Alessandro Sergio @AlesSergio19
20 Followers 413 Following
Prof.Riquim @ProfRiquim
211 Followers 4K Following I'm married, 1 child, good future prospects for the next generations Namastê. #STEM #Edtech #EdAI @Xprize @Ycombinator @wefunder @CES #Febrace #ISEF #Biohacking
Lewis 🇺🇸 @ctjlewis
46K Followers 21K Following Startup counterculture. LLMs. If you think I might be able to help you with something, ask.
Graebert India - ARES... @GraebertIndia
275 Followers 521 Following DWG-based CAD software for Windows, macOS, Linux, Web & Mobile | AutoCAD Alternative | Powered by AI & Cloud | Try ARES CAD Today!
Chris Chabot @chabotc
3K Followers 2K Following Your product is safe on localhost, but that is not what products are built for. Developer Relations at @iGent_AI
Cristiano Filho @crisfilho98
32 Followers 557 Following Salesforce Developer at @Capgemini Visit my website: https://t.co/br0Mm6d1ck
AndyZ @AndyZhuang321
44 Followers 489 Following believe that oriental culture can really make a positive impact on this world
Granato99 @granato99
3 Followers 158 Following
stewardscience2930 @stewardsci17850
77 Followers 2K Following Medical and Scientific Writer. Interested in Genomics, Biotech, Tech & Computing
Mahboob @mahboob_imt
755 Followers 5K Following Building something big on #deSci.. Editor @labcritics .. In a previous like Founder of JournalorErrology, Zraya, UnSelf/KarmaSnap and a few other co's..
Dadddy Malie @DadddyMali93946
31 Followers 784 Following
LabCritics @LabCritics
2K Followers 3K Following Follow us to know about new Lab Tech, Software and Services, even consumables... Reach out if you are building for researchers
José Crespo-Barrios,... @jcb_31416
2K Followers 695 Following 50 bio | 50 web3. ceo of regeneratics. angioimmunoregenerative, microbiology. edu: phd aerospace eng. others: maths, ML/DL, web3 fullstack dev.
Jason Sun @JasonSunTweets
21 Followers 279 FollowingAl Gonzalez @algonzalez
380 Followers 2K Following Programmer (previously owned by a greyhound named Denny).
Shanheguren @YUKAILiu4
92 Followers 3K Following
Asa Hidmark @Nymne
6K Followers 2K Following 🇪🇺 🇫🇷 🇸🇪 scientist living in 🇩🇪 What Mythos does for cyber security, I do for scientific figures https://t.co/HX73uezNQm.
Kiko @Kikohenrique44
21 Followers 1K Following
Silicon-Based Human @Jmoran07235302
48 Followers 2K Following
JShan @jshannon45
106 Followers 240 Following
Rob Albert @FoundersJoining
32 Followers 424 Following Online 🦕 since dial-up. Internet marketing hustler & SEO since '99. Slow learner, lazy executor… Somehow I still occasionally make it work.
🧠 Ahmet KALAYCI �... @akalayci34
3K Followers 7K Following LinkedIn: kalaycia الزهور Pine roars with boughs 𐰴𐰍𐰣 #NFTResidency #Metanomics #MetaWeb 🕸️3⃣ https://t.co/3QW8NAh8Cs 🌉🦙🎇🧩🎨🏗️🏭 🦊🪙⛓️🏦🥽
أسامة الغام... @DrAlMoalla
779 Followers 6K Following طبيب عناية حرجة أطفال | Pediatric ICU Fellow | (فما ظنكم برب العالمين)
Nathan Labenz @labenz
17K Followers 3K Following AI Scout, building text-2-video @Waymark, host of The Cognitive Revolution podcast
Gajanan Ghodake @Ghodake
180 Followers 2K Following Assoc. Prof. | Dongguk Univ., Seoul 🇰🇷 🌱 Green tech | SDGs | 🌍 Sustainability | 🔬 Nano-innovation 📧[email protected] h-index 53
Paresh @Paresh656062216
5 Followers 741 Following
Rebecca Torn @TornRebecc22289
14 Followers 450 Following
LetitiaHope @M9e6chB65yg4tA
38 Followers 1K Following
BonnieBarney @73GK4tglokk8ik
18 Followers 1K Following
Tom Ellis @ProfTomEllis
26K Followers 593 Following Synthetic Biology & Synthetic Genomics @ Imperial College London and the Sanger Institute. Bilingual in English and DNA. D-/L-
Jake Wintermute 🧬/... @SynBio1
17K Followers 425 Following Synthetic Biologist - Foundry Theorist - American Wetware - stay humble biodesigners
Jason Kelly @jrkelly
33K Followers 3K Following Co-founder and CEO at Ginkgo Bioworks ($DNA)🧬 Former Chair of US National Security Commission on Emerging Biotechnology 🇺🇸
John Cumbers @johncumbers
19K Followers 2K Following The room where bio partnerships get made. F500 BD, VCs, and 2,000 founders — all in San Jose, May 4–7. https://t.co/wdTABwo6of
Víctor de Lorenzo @vdlorenzo_CNB
14K Followers 26 Following Not very active in X, if interested please follow me in https://t.co/dmH9Fg5MQq
Jim Haseloff @jimhaseloff
5K Followers 459 Following Plant Synthetic Biology and Biomaker: accessible tools for bioengineering, @jimhaseloff.bsky.social
Olivier Borkowski @O_Borkowski
7K Followers 2K Following Tenured Scientist in Synthetic Biology (INRAE, Paris Area) Cell-Free ⦁ Bioengineering ⦁ Microbiology 》》》》》Also on bluesky 》》》》》https://t.co/4zpI5kUf4A
Renee Wegrzyn @rwegrzyn
4K Followers 1K Following Inaugural Director, Advanced Research Projects Agency for Health
Mo Khalil @MoKhalilLab
10K Followers 2K Following Prof. @ Harvard University, Broad Institute, and Wyss Institute. Understanding the natural world by building a synthetic one. website: https://t.co/PyjGQRHoUy
Patrick Boyle — e/�... @p_maverick_b
6K Followers 1K Following Working on design language for biology @americanwetware. iCSO @officialatcc. Previously CSO at Ginkgo Bioworks. @patrickboyle on 🟦☁️
whimsy lohan (in SF) @SexyLikeMeiosis
11K Followers 995 Following helping scientists build cool shit @convergent_FROs, writing at Contents May Shift // "an interesting mix of spiritual and hustler" according to my landlord
Christina Agapakis @thisischristina
13K Followers 2K Following “If chaotic good was a biologist” 🧬🦠🧫🌱🥩🌽🦀🐉 working wherever biology, technology, and people collide at https://t.co/IJdNoFq1mI and @americanwetware
Sri Kosuri @srikosuri
19K Followers 3K Following Cofounder & CEO, @octantbio ; BoD @Ginkgo ; Husband of @karinlynnalm ; Previously Associate Professor, @uclachem
Christopher Voigt @Geneticdesigner
11K Followers 825 Following Composing DNA / Professor and Department Head @ MIT Biological Engineering
Twist Bioscience @TwistBioscience
26K Followers 802 Following Synthetic DNA for Health & Sustainability #WeMakeDNA #TwistBlog #WritingTheFuture #TwistBiopharma #ScienceDoesntStop #DiversityIsInOurDNA
Maxx Chatsko @MaxxChatsko
7K Followers 254 Following Founder @Solt_DB a biotech equities research firm and public benefit company.
Howard Salis @hsalis
4K Followers 263 Following Professor of synthetic biology & chemical engineering. De Novo DNA founder. Engineering microbes with predictive models & algorithms.
Thomas Gorochowski @chofski
4K Followers 2K Following Synthetic biologist, programmer of cells, and lover of all things visual. Wakes up in the morning to learn some of natures secrets and do a spot of fly fishing.
Ross Cloney @rosscloney
3K Followers 475 Following Chief Editor for Biotechnology @NatureComms Synthetic Biology & Solarpunk Tweets are my own thoughts. he/him 🏳️🌈
geoff @GeoffreyHuntley
82K Followers 2K Following pondering the ponderoos about AI in application in unhinged ways and doing it. building @latentpatterns and the space loom. i created the “ralph loop”. iykyk
Nathan Labenz @labenz
17K Followers 3K Following AI Scout, building text-2-video @Waymark, host of The Cognitive Revolution podcast
Tobias Halloran @tobiashalloran
357 Followers 729 Following Director @NVIDIA Startups, EMEAI. Philosophy & AI at HAI Lab; CS @ University of Oxford. Views & opinions my own and not that of my employer.
Nikolay Savinov @SavinovNikolay
4K Followers 0 Following Research @OpenAI Ex-DeepMind. Worked on LLM pretraining for Gemini and co-led 10M-context work for Gemini 1.5 ♊
doomslide @doomslide
12K Followers 874 Following unprecedented times call for unprecedented bullshit
wordgrammer @wordgrammer
26K Followers 2K Following The vice of our era is resentment towards great men. 6’3 btw
xjdr @_xjdr
28K Followers 689 Following building AI that wont embarrass me in front of my own standards
Logan Kilpatrick @OfficialLoganK
330K Followers 3K Following Member of technical staff, working on Gemini, @GoogleAIStudio, the Gemini API, & Kaggle. My views!
Laura Modiano @LauraModiano
8K Followers 760 Following Founder Experience @OpenAI Building for Builders
👩💻 Paige Bai... @DynamicWebPaige
75K Followers 2K Following ✨ AI should be about empowering humans, building understanding, and making dreams realities. 👩💻 DevX Eng. Lead @GoogleDeepMind ex-@GitHub || views = my own!
Logan Graham @logangraham
21K Followers 8K Following Head of the Frontier Red Team @anthropicai. 🌎 Make things radically good.
Yuxiang Wu @yuxiangwu_
2K Followers 1K Following Building safe self-evolving AI|Co-founder @WecoAI | LLM, NLP, ML
Ian Hogarth @soundboy
25K Followers 4K Following investor at @pluralplatform, chair UK AI Security Institute, co-founder @songkick
Alexandr Notchenko @Gang1man
783 Followers 4K Following Engineer ⋂ Scientist ⋂ Maker Senior MLE at https://t.co/4wb4D1F9vZ PhD grad from @Skoltech Run ODS London and @ods_ai
Amanda Askell @AmandaAskell
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Omar Khattab @lateinteraction
36K Followers 3K Following asst professor @MIT CSAIL @nlp_mit. https://t.co/VgyLxl0VZz, https://t.co/ZZaSzaRIOF (@DSPyOSS), RLMs, GEPA, Pedagogical RL
OpenAI Developers @OpenAIDevs
355K Followers 1 Following Official updates for developers building with Codex & the OpenAI Platform • Service status: https://t.co/kZwnwdYYEq
anton @abacaj
48K Followers 607 Following
Jimmy Apples 🍎/acc @apples_jimmy
59K Followers 2K Following Wagmi. 2025. As featured in Bloomberg. As quoted by Nobel Prize winner Demis Hassabis. As mentioned on the Lex Fridman Podcast💺
OSINTdefender @sentdefender
2.3M Followers 2K Following Open Source Intelligence Monitor focused on Europe and Conflicts across the World. RT ≠ Endorsement. Want to Support my Work? https://t.co/PcUbewvWPr
Simon Willison @simonw
190K Followers 6K Following Creator @datasetteproj, co-creator Django. PSF board. Hangs out with @natbat. He/Him. Mastodon: https://t.co/t0MrmnJW0K Bsky: https://t.co/OnWIyhX4CH
Alex Kendall @alexgkendall
17K Followers 715 Following CEO at @wayve_ai teaching cars how to drive with machine learning 🇳🇿
Ought @oughtinc
2K Followers 18 Following Automate & scale open-ended reasoning Building @elicitorg, an AI research assistant Demos https://t.co/8UGlbJ1eVE Jobs & product roadmap https://t.co/oDFh35ACEG
Maggie Appleton @Mappletons
41K Followers 1K Following Staff Research Engineer at @GitHubNext. But actually a designer. Writes about design, dev, & anthropology. Also on Bluesky 🦋 @maggieappleton.com
Stephanie Zhan @stephzhan
32K Followers 2K Following GP @Sequoia, investing in AI, from company formation. 1st partner to @linear @mach_industries @middeskhq @reflection_ai @ricursiveai @skildai @tavus
𝔊𝔴𝔢𝔯𝔫 @gwern
75K Followers 108 Following Internet besserwisser; pedantic, mean reply guy. 𝘞𝘢𝘵𝘢𝘴𝘩𝘪 𝘬𝘪𝘯𝘪𝘯𝘢𝘳𝘪𝘮𝘢𝘴𝘶! (Follow requests ignored due to terrible UI.)
John Nay @johnjnay
15K Followers 65 Following founder & CEO of Norm Ai // founding CEO of Brooklyn AI (acquired by TIAA Nuveen) // more at https://t.co/IpzZqFixUk
Miltos Allamanis 🇪... @miltos1
1K Followers 321 Following Researching deep learning for generating and understanding programs. Research Scientist @GoogleAI Also at @[email protected] (Opinions are my own.)
Shibo Hao @Ber18791531
2K Followers 1K Following Ph.D. candidate @UCSanDiego B.S. in CS @PKU1898 RS intern @AIatMeta @Bloomberg Ph.D. Fellow 🥥Coconut, 🎶Reasoning-via-planning, 🛠️ToolkenGPT
Abhishek Sinha @abysinha
949 Followers 2K Following Product@Google Cloud Vertex AI. Prev Nvidia,Cohere, AWS. West Wing watcher. Maker of bad cocktails. Test Cricket Snob.
Charles Sutton @RandomlyWalking
17K Followers 1K Following Research scientist @GoogleAI / Previously academic @InfAtEd / Deep learning to help people write code. / @[email protected] / ❤️s:🐱🐶☕️🍕































