Jake Freimer (@[email protected]) @JakeFreimer

Joined July 2013

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192
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115

Jake Freimer (@[email protected]) @JakeFreimer

4 years ago

I’m hiring a computational scientist 3 at Genentech to analyze cutting-edge single-cell genomics and high-throughput screening data in an extremely collaborative environment focused on finding cures for disease. Please reach out to learn more. careers.gene.com/us/en/job/GENE…

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Jake Freimer (@[email protected]) @JakeFreimer

4 years ago

@Dr_Nathere You can apply directly at the link: careers.gene.com/us/en/job/GENE…

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Hakhamanesh Mostafavi @Hakha_Most

4 years ago

We've known for a long time that a large fraction of noncoding GWAS hits are not currently explained by eQTLs. Why?? I'm excited to share our new preprint on this! Take home: GWAS and eQTL assays maximize power for different types of variants. (1/n) biorxiv.org/content/10.110…

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Sagar Bapat @bapat_lab

4 years ago

Thrilled to share findings published today @Nature from our lab in collaboration with @MarsonLab @GladstoneInst and two labs (Ye Zheng and Ron Evans) @salkinstitute. nature.com/articles/s4158…

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Jake Freimer (@[email protected]) @JakeFreimer

4 years ago

@AirbnbHelp 10 hours later and Airbnb is waiting to hear from our host if they can fix the problem, but no one can reach the host. @Airbnb @AirbnbHelp solution is to just keep waiting for the host even if that takes days.

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Zach Steinhart @CrisprEh

4 years ago

Thrilled to have our recent work from the @marsonlab published in @ScienceMagazine science.org/doi/10.1126/sc…. This was the result of an awesome collaboration between myself and fellow Marson Lab postdoc, @R_Schmidt_ (1/12)

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Stacie Dodgson, PhD @StacieDodgson

5 years ago

The @MarsonLab has a position open for a research associate to work on gene regulatory network mapping in human immune cells. Check out this related preprint: biorxiv.org/content/10.110… & apply here: bit.ly/3ohe4rM

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William J. Greenleaf @WJGreenleaf

5 years ago

Excited to announce that our paper describing NEAT-seq, a method to simultaneously measure transcription factor protein abundance, ATAC-seq, and RNA-seq in single cells, is out on biorxiv! Congrats to Amy and Ben! biorxiv.org/content/10.110…

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Daniel Bryan Goodman @dbgoodman

5 years ago

Excited to share new work w/ co-lead @CamilliaAzimi, @MarsonLab @kickassscience1 @roybal_lab: using a method we call 'CAR Pooling', we tested many CARs in multiplex & found new non-T cell signaling domains which improve CAR-T efficacy. biorxiv.org/cgi/content/sh… 👇🧵 1/10

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Zach Steinhart @CrisprEh

5 years ago

Excited to share our recent preprint from the @marsonlab, where we used complementary genome-wide CRISPRa and CRISPRi screens to map regulators of cytokine response in primary human T cells. Terrific collaboration with fellow Marson Lab postdoc, Ralf Schmidt @R_Schmidt_! (1/15)

bioRxiv @biorxivpreprint

5 years ago

CRISPR activation and interference screens in primary human T cells decode cytokine regulation biorxiv.org/cgi/content/sh… #bioRxiv

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Jake Freimer (@[email protected]) @JakeFreimer

5 years ago

@johnomix @nevillesanjana @tuuliel Cool preprint. Looks like CRISPRiV2 is much better for enhancers, did you try any of the other recent CRISPRi constructs such as using ZIM3 or the Weissman CRISPRoff with DNMT3A? When target gene is the 2nd closets gene, is the closest gene not expressed?

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Jake Freimer (@[email protected]) @JakeFreimer

5 years ago

@andy_utoronto @tuuliel_lab @davisjmcc @jkpritch some other tissues which might function in more isolation and disease risk might be more cell intrinsic. 3/3

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Jake Freimer (@[email protected]) @JakeFreimer

5 years ago

@andy_utoronto @tuuliel_lab @davisjmcc @jkpritch for functional studies. On the other hand, the immune system interacts with every other tissue/microbiome so it's going to be more complicated to measure the contribution of these interactions on disease risk compared to 2/3

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Jonathan Pritchard @jkpritch

5 years ago

How can we systematically measure gene regulatory networks around key disease genes? Excited to share our new work using CRISPR KOs in primary T cells, with @MarsonLab, led by @JakeFreimer and Oren Shaked: biorxiv.org/content/10.110…

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Sri Kosuri @srikosuri

6 years ago

Big new serology study from @MarsonLab @pdhsu et al. Lots of really detailed data on 12 different tests (10 lateral flow, 2 ELISAs). A lot of disagreement and specificity issues. Super detailed and important work. covidtestingproject.org/index.html

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Jimmie Ye @yimmieg

6 years ago

Really amazing work co-lead by my student @cody_mowery, the @MarsonLab and @pdhsu to show the performance of serological assays (lateral flow and ELISA) for detecting Sars2-CoV-2 antibodies: covidtestingproject.org.

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Jonathan Pritchard @jkpritch

6 years ago

Our latest: "GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background": biorxiv.org/content/10.110… We use urate, IGF-1, and testosterone as model molecular traits to learn general principles about the architecture of complex traits.